Prevalence and risk factors for hepatitis B and C viruses in patients with leprosy

In 403 leprosy patients, anti-HBc and anti-HCV prevalence were similar to general population. Health-related job and lower educational level were associated to anti-HBc positivity. [Display omitted] •Anti-HBc and anti-HCV prevalence in leprosy was similar to general population.•Non detection of HBsA...

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Bibliographic Details
Published in:Acta tropica 2017-08, Vol.172, p.160-163
Main Authors: Costa, J.E.F., Morais, V.M.S., Gonçales, J.P., Silva, D.M., Coêlho, M.R.C.D.
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers - blood
Brazil - epidemiology
Enzyme-Linked Immunosorbent Assay
Female
Hepacivirus - isolation & purification
Hepatitis B - complications
Hepatitis B - virology
Hepatitis B Antibodies
Hepatitis B Surface Antigens
Hepatitis B virus
Hepatitis B virus - isolation & purification
Hepatitis C - complications
Hepatitis C - virology
Hepatitis C Antibodies
Hepatitis C virus
Humans
Leprosy
Leprosy - complications
Leprosy - virology
Male
Middle Aged
Prevalence
Real-Time Polymerase Chain Reaction
Risk Factors
Seroepidemiologic Studies
Serologic Tests
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Summary:In 403 leprosy patients, anti-HBc and anti-HCV prevalence were similar to general population. Health-related job and lower educational level were associated to anti-HBc positivity. [Display omitted] •Anti-HBc and anti-HCV prevalence in leprosy was similar to general population.•Non detection of HBsAg suggests that there is no propensity for chronic infection.•Anti-HBc was associated with health-related job and lower educational level.•There was no association between serological markers and leprosy reactional episodes. It has been reported a higher seroprevalence of HBV and HCV in leprosy patients than in the general population, but the reasons for these findings are not yet clear. On the other hand, there is evidence that these viruses may influence the onset of leprosy reactional episodes, an important cause of neurological sequelae. This study aimed to determine seroprevalence and risk factors for HBV and HCV in leprosy patients and to investigate its association with leprosy reactions. Patients attended from 2015 to 2016 at a Reference Center in Leprosy in Northeastern region of Brazil, were interviewed, had their records reviewed to investigate biological, clinical, behavioral and socioeconomic factors, and underwent blood sample collection. Biological samples were tested for HBV (HBsAg, anti-HBs and anti-HBs) and HCV (anti-HCV) serological markers by ELISA and, in anti-HCV positive samples, HCV RNA was screened by real time PCR. SPSS program was used to analyze the data. A total of 403 leprosy patients were included. Although anti-HBc was positive in 14.1%, there was no detection of HBsAg, which contradicts the hypothesis that leprosy patients have immune deficit that make them more prone to chronic HBV infection. Multibacillary leprosy (0.057), health-related work (0.011) and lower educational level (0.035) were associated with anti-HBc positivity. Anti-HCV was positive in 0.5%, with no detection of HCV RNA. No association was identified between anti-HCV and the epidemiological analyzed factors. There was also no association of anti-HBc or anti-HCV with type 1 or type 2 leprosy reactions. Thus, the seroprevalence of HBV and HCV in leprosy patients was similar to that of the general population of Northeastern region of Brazil, and no association of HBV or HCV with leprosy reactions was observed.
ISSN:0001-706X
1873-6254
DOI:10.1016/j.actatropica.2017.04.024