Unraveling molecular pathways of poorly differentiated neuroendocrine carcinomas of the gastroenteropancreatic system: A systematic review

Highlights • Extra-pulmonary high grade neuroendocarcinomas of the gastrointestinal tract are rare and aggressive. • Alterations in TP53 and Cyclin D1 pathway and common in these tumors. • Many molecular alterations can be targeted with new cancer-directed agents. • Their molecular features resemble...

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Bibliographic Details

Published in:	Cancer treatment reviews 2017-05, Vol.56, p.28-35
Main Authors:	Girardi, Daniel M, Silva, Andrea C.B, Rêgo, Juliana Florinda M, Coudry, Renata A, Riechelmann, Rachel P
Format:	Article
Language:	eng
Subjects:	Cancer Cell Differentiation - physiology Gastrointestinal Neoplasms - genetics Gastrointestinal Neoplasms - metabolism Gastrointestinal Neoplasms - pathology Hematology, Oncology and Palliative Medicine Humans Microsatellite Instability Molecular Mutation Neuroendocrine Carcinoma Neuroendocrine tumors Neuroendocrine Tumors - genetics Neuroendocrine Tumors - metabolism Neuroendocrine Tumors - pathology p53 Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology
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