Cyclodextrin Nanoparticles Bearing 8‐Hydroxyquinoline Ligands as Multifunctional Biomaterials

Cyclodextrins are used as building blocks for the development of a host of polymeric biomaterials. The cyclodextrin polymers have found numerous applications as they exhibit unique features such as mechanical properties, stimuli responsiveness and drug loading ability. Notwithstanding the abundance...

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Bibliographic Details
Published in:Chemistry : a European journal 2017-03, Vol.23 (18), p.4442-4449
Main Authors: Oliveri, Valentina, Bellia, Francesco, Vecchio, Graziella
Format: Article
Language:English
Subjects:
Agglomeration
Amyloid beta-Peptides - chemistry
Amyloid beta-Peptides - metabolism
antiaggregant
antioxidant
Antioxidants - chemistry
Bearing
beta-Cyclodextrins - chemistry
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Biomaterials
Biomedical materials
Chemistry
copper
Copper - chemistry
Cyclodextrins
Cyclodextrins - chemistry
Dynamic Light Scattering
Hydroxyquinolines - chemistry
Ligands
Magnetic Resonance Spectroscopy
Nanoparticles
Nanoparticles - chemistry
Nephelometry and Turbidimetry
Particle Size
polymer
Polymers
Protein Aggregates - drug effects
Spectrophotometry
Surgical implants
zinc
Zinc - chemistry
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Summary:Cyclodextrins are used as building blocks for the development of a host of polymeric biomaterials. The cyclodextrin polymers have found numerous applications as they exhibit unique features such as mechanical properties, stimuli responsiveness and drug loading ability. Notwithstanding the abundance of cyclodextrin polymers studied, metal‐chelating polymers based on cyclodextrins have been poorly explored. Herein we report the synthesis and the characterization of the first metal‐chelating β‐cyclodextrin polymer bearing 8‐hydroxyquinoline ligands. The metal ions (Cu2+ or Zn2+) can modulate the assembly of the polymer nanoparticles. Moreover, the protective activity of the new chelating polymer against self‐ and metal‐induced Aβ aggregation and free radical species are significantly higher than those of the parent compounds. These synergistic effects suggest that the incorporation of hydroxyquinoline moieties into a soluble β‐cyclodextrin polymer could represent a promising strategy to design multifunctional biomaterials. Going metallic: The metal ions (Cu2+ or Zn2+) can modulate the assembly of the novel metal‐chelating β‐cyclodextrin polymer bearing 8‐hydroxyquinoline ligands. The synergistic effect of cyclodextrins and quinolines determines the high inhibitory modulation toward self‐ and metal‐induced Aβ aggregation.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201700031