Iodine-mediated oxidative annulation for one-pot synthesis of pyrazines and quinoxalines using a multipathway coupled domino strategy

An efficient iodine-mediated oxidative annulation of aryl acetylenes-arylethenes-aromatic ketones with 1,2-diamines for the synthesis of pyrazines and regioselective synthesis of quinoxalines is presented. A multipathway coupled domino approach has been developed for the one-pot synthesis of 1,4-dia...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-11, Vol.50 (88), p.13517-13520
Main Authors: Viswanadham, K K Durga Rao, Prathap Reddy, Muktapuram, Sathyanarayana, Pochampalli, Ravi, Owk, Kant, Ruchir, Bathula, Surendar Reddy
Format: Article
Language:English
Subjects:
Chemical reactions
Compatibility
Cyclization
Diamines - chemistry
Ethylenes - chemistry
Iodine - chemistry
Ketones
Organic chemistry
Oxidation-Reduction
Pyrazines
Pyrazines - chemical synthesis
Pyrazines - chemistry
Quinoxalines
Quinoxalines - chemical synthesis
Quinoxalines - chemistry
Stereoisomerism
Strategy
Synthesis
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Summary:An efficient iodine-mediated oxidative annulation of aryl acetylenes-arylethenes-aromatic ketones with 1,2-diamines for the synthesis of pyrazines and regioselective synthesis of quinoxalines is presented. A multipathway coupled domino approach has been developed for the one-pot synthesis of 1,4-diazines with high functional group compatibility.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc05844e