Clinical staging and serum cytokines in bipolar patients during euthymia

Changes in serum cytokines and altered neutrophin concentration have been associated with bipolar disorder (BD). Our aim here was to analyze peripheral blood biomarkers according to the clinical stages of BD. Euthymic BD-I patients were grouped according to their level of functioning in early-stage...

Full description

Saved in:
Bibliographic Details
Published in:Progress in neuro-psychopharmacology & biological psychiatry 2017-07, Vol.77, p.194-201
Main Authors: Tatay-Manteiga, Amparo, Balanzá-Martínez, Vicent, Bristot, Giovana, Tabarés-Seisdedos, Rafael, Kapczinski, Flavio, Cauli, Omar
Format: Article
Language:English
Subjects:
Acute-Phase Proteins - metabolism
Adult
Affect
Biomarkers - blood
Bipolar disorder
Bipolar Disorder - blood
Bipolar Disorder - diagnosis
Bipolar Disorder - psychology
Blood Cell Count
Brain-Derived Neurotrophic Factor - blood
Case-Control Studies
Clinical staging
Cytokines
Cytokines - blood
Female
Humans
Inflammation
Interleukin-10 - blood
Interleukin-6 - blood
Leukocytes
Male
Middle Aged
Nerve Growth Factors - blood
Neurotrophins
Siblings
Tumor Necrosis Factor-alpha - blood
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Changes in serum cytokines and altered neutrophin concentration have been associated with bipolar disorder (BD). Our aim here was to analyze peripheral blood biomarkers according to the clinical stages of BD. Euthymic BD-I patients were grouped according to their level of functioning in early-stage (n=25) and late-stage (n=23), and compared to healthy siblings (n=23) and genetically unrelated healthy controls (n=21). Neurotrophin (neurotrophin-3 and BDNF) concentration and biomarkers of inflammation, including cytokines (IL-6, IL-10 and TNF-α), leukocytes count and acute phase proteins, were measured. IL-10 concentration was significantly increased in early-stage patients compared to late-stage patients, healthy siblings and controls whereas TNF-α concentration was significantly increased in late-stage patients compared to controls. Total leukocytes, neutrophil and monocyte count were significantly increased in late-stage patients compared to healthy siblings and controls. The concentration of IL-6, neurotrophin-3 and BDNF was unchanged in euthymia. Healthy siblings did not show significant changes in any biomarker. The concentration of IL-10, TNF-α, neutrophil and monocytes subtype count in blood is altered in patients with BD during euthymic state. The link between peripheral inflammation and different stages in BD deserves further studies. •The concentration of IL-10, TNF-α, neutrophil, monocytes in blood is altered in patients with bipolar disorder (BD) during euthymia.•The changes depend on the clinical stages of BD.•There is an association between peripheral inflammation and early- and late-stages of BD during euthymia.
ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2017.04.028