Chemical and Biological Aspects of Nutritional Immunity—Perspectives for New Anti‐Infectives that Target Iron Uptake Systems

Upon bacterial infection, one of the defense mechanisms of the host is the withdrawal of essential metal ions, in particular iron, which leads to “nutritional immunity”. However, bacteria have evolved strategies to overcome iron starvation, for example, by stealing iron from the host or other bacter...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2017-11, Vol.56 (46), p.14360-14382
Main Authors: Bilitewski, Ursula, Blodgett, Joshua A. V., Duhme‐Klair, Anne‐Kathrin, Dallavalle, Sabrina, Laschat, Sabine, Routledge, Anne, Schobert, Rainer
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibacterial materials
Antibiotic resistance
Antibiotics
Bacteria
Bacteria - drug effects
Bacteria - metabolism
Bacterial Infections - immunology
Bacterial Infections - metabolism
Chelating agents
Heme - metabolism
heme proteins
Homeostasis
Host-Pathogen Interactions
Humans
Immunity
Interception
Iron
Iron - metabolism
Metals
Microbial Sensitivity Tests
nutritional immunity
siderophores
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Summary:Upon bacterial infection, one of the defense mechanisms of the host is the withdrawal of essential metal ions, in particular iron, which leads to “nutritional immunity”. However, bacteria have evolved strategies to overcome iron starvation, for example, by stealing iron from the host or other bacteria through specific iron chelators with high binding affinity. Fortunately, these complex interactions between the host and pathogen that lead to metal homeostasis provide several opportunities for interception and, thus, allow the development of novel antibacterial compounds. This Review focuses on iron, discusses recent highlights, and gives some future perspectives which are relevant in the fight against antibiotic resistance. Fighting fit: The fight for essential metal ions is like a tug of war between pathogens and host cells. Interference in this struggle can lead to new ways to fight antibiotic resistance.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201701586