Increased risk of incident osteoporosis and osteoporotic fracture in tuberculosis patients: a population-based study in a tuberculosis-endemic area

Summary The occurrence of osteoporosis in tuberculosis, a chronic infection, has rarely been evaluated. In this study, we found significantly higher incidence rates of osteoporosis (Adjusted hazard ratio (AHR) 1.82) and osteoporotic fracture (AHR 2.33) in tuberculosis patients than matched cohorts,...

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Bibliographic Details
Published in:Osteoporosis international 2017-05, Vol.28 (5), p.1711-1721
Main Authors: Chen, Y.-Y., Feng, J.-Y., Ting, W.-Y., Yen, Y.-F., Chuang, P.-H., Pan, S.-W., Su, V. Y.-F., Su, W.-J.
Format: Article
Language:English
Subjects:
Adult
Aged
Asthma
Case-Control Studies
Chronic infection
Chronic obstructive pulmonary disease
Comorbidity
Databases, Factual
Endemic Diseases
Endocrinology
Female
Fractures
Health risk assessment
Humans
Incidence
Infectious diseases
Inflammatory diseases
Kaplan-Meier Estimate
Lung diseases
Male
Medicine
Medicine & Public Health
Middle Aged
Multivariate analysis
Mycobacterium
Obstructive lung disease
Original Article
Orthopedics
Osteoporosis
Osteoporosis - epidemiology
Osteoporosis - microbiology
Osteoporotic Fractures - epidemiology
Osteoporotic Fractures - microbiology
Population studies
Population-based studies
Rheumatology
Risk Factors
Socioeconomic Factors
Taiwan - epidemiology
Tuberculosis
Tuberculosis - complications
Tuberculosis - epidemiology
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Summary:Summary The occurrence of osteoporosis in tuberculosis, a chronic infection, has rarely been evaluated. In this study, we found significantly higher incidence rates of osteoporosis (Adjusted hazard ratio (AHR) 1.82) and osteoporotic fracture (AHR 2.33) in tuberculosis patients than matched cohorts, which suggest that osteoporosis screening should be considered in tuberculosis patients’ follow-up program. The aim of this study is to determine the occurrence of incident osteoporosis in patients who completed anti-tuberculosis (TB) treatment. Introduction Chronic inflammatory disorders are associated with an increased risk of osteoporosis. Although TB is an infectious disease characterized by systemic inflammatory responses, the impact of active TB on incident osteoporosis is unclear. We used the Taiwan National Health Insurance Research Database to investigate the association between history of active TB and incident osteoporosis and osteoporotic fracture. Methods In this nationwide retrospective cohort study, active TB patients and their age- and sex-matched controls were identified from the National Health Insurance Research Database in Taiwan during 2000–2012. The occurrence of incident osteoporosis, osteoporotic fractures, and risk factors associated with osteoporosis among TB patients and matched controls were analyzed. Results We observed incident osteoporosis in 2.2% ( n  = 86) of the TB patients and in 1.1% ( n  = 162) of the matched controls. The incidence rate of osteoporosis was 4.31 and 1.80 per 1000 person-years, which was significantly higher in TB patients ( p  
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-017-3939-x