White matter atrophy and myelinated fiber disruption in a rat model of depression

Brain imaging and postmortem studies have indicated that white matter abnormalities may contribute to the pathology and pathogenesis of depression. However, until now, no study has quantitatively investigated white matter changes in depression in rats. The current study used the chronic unpredictabl...

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Bibliographic Details
Published in:Journal of comparative neurology (1911) 2017-06, Vol.525 (8), p.1922-1933
Main Authors: Gao, Yuan, Ma, Jing, Tang, Jing, Liang, Xin, Huang, Chun‐Xia, Wang, San‐rong, Chen, Lin‐mu, Wang, Fei‐Fei, Tan, Chuan‐Xue, Chao, Feng‐Lei, Zhang, Lei, Qiu, Xuan, Luo, Yan‐Min, Xiao, Qian, Du, Lian, Tang, Yong
Format: Article
Language:English
Subjects:
Animals
Atrophy - pathology
Attention Deficit Hyperactivity Disorder
Blotting, Western
chronic unpredictable stress
depression
Depression - pathology
Disease Models, Animal
Male
Microscopy, Electron, Transmission
myelinated fibers
Nerve Fibers, Myelinated - pathology
Rats
Rats, Sprague-Dawley
Rodents
RRID: AB_956157
RRID: SCR_002526
stereology
Studies
white matter
White Matter - pathology
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Summary:Brain imaging and postmortem studies have indicated that white matter abnormalities may contribute to the pathology and pathogenesis of depression. However, until now, no study has quantitatively investigated white matter changes in depression in rats. The current study used the chronic unpredictable stress (CUS) model of depression. Body weight and sucrose preference test (SPT) scores were assessed weekly. Upon successfully establishing the CUS animal model, all animals were tested using the SPT and the open field test (OFT). Then, transmission electron microscopy and unbiased stereological methods were used to investigate white matter changes in the rats. Compared with the control group, the body weight and sucrose preference of the CUS rats were significantly decreased (p 
ISSN:0021-9967
1096-9861
DOI:10.1002/cne.24178