IL‐17 and IL‐22 in immunity: Driving protection and pathology

IL‐17 and IL‐22 are tissue‐signaling cytokines that favor protection and regeneration of barrier organs such as the skin, lung, and gastrointestinal system. Both cytokines share cellular sources, signaling pathways, and functional aspects; however, taking a closer look they differ, e.g. in their pro...

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Bibliographic Details
Published in:European journal of immunology 2017-04, Vol.47 (4), p.607-614
Main Authors: Eyerich, Kilian, Dimartino, Valentina, Cavani, Andrea
Format: Article
Language:English
Subjects:
Animals
autoimmune diseases
Autoimmunity
Cytokines
Humans
Immunity
Infections - immunology
Interleukin-17 - immunology
Interleukin-22
Interleukins - immunology
Intestines - immunology
Lung - immunology
Neoplasms - immunology
Pathology
Regeneration
Signal Transduction
Skin - immunology
Th17
Th17 Cells - immunology
Th22
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Summary:IL‐17 and IL‐22 are tissue‐signaling cytokines that favor protection and regeneration of barrier organs such as the skin, lung, and gastrointestinal system. Both cytokines share cellular sources, signaling pathways, and functional aspects; however, taking a closer look they differ, e.g. in their pro‐inflammatory or regenerative potential. An imbalance of the carefully orchestrated tissue‐signaling system might result in autoimmune diseases, promote cancer growth, or predispose to infectious diseases. This review highlights recent understandings in cellular sources, signaling mechanisms, physiologic as well as pathogenic role of the double‐faceted cytokines IL‐17 and IL‐22. IL‐17 and IL‐22 exert protective functions in boundary organs such as skin, lung, and gastrointestinal tract. However, an imbalance of the orchestrated tissue‐signaling system might result in autoimmune diseases, promote cancer growth or predispose to infectious diseases.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.201646723