Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women

Lappe et al determine whether dietary supplementation with vitamin D^sub 3^ and calcium reduces the risk of cancer among older women. At year 1, serum 25-hydroxyvitamin D levels were 43.9 ng/mL in the vitamin D^sub 3^ + calcium group and 31.6 ng/mL in the placebo group. A new diagnosis of cancer was...

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Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 2017-03, Vol.317 (12), p.1234-1234
Main Authors: Lappe, Joan, Watson, Patrice, Travers-Gustafson, Dianne, Recker, Robert, Garland, Cedric, Gorham, Edward, Baggerly, Keith, McDonnell, Sharon L
Format: Article
Language:English
Subjects:
Calcium
Cancer
Clinical trials
Dietary supplements
Vitamin D
Womens health
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Summary:Lappe et al determine whether dietary supplementation with vitamin D^sub 3^ and calcium reduces the risk of cancer among older women. At year 1, serum 25-hydroxyvitamin D levels were 43.9 ng/mL in the vitamin D^sub 3^ + calcium group and 31.6 ng/mL in the placebo group. A new diagnosis of cancer was confirmed in 109 participants, 45 (3.89%) in the vitamin D^sub 3^ + calcium group and 64 (5.58%) in the placebo group (difference, 1.69% [95% CI, -0.06% to 3.46%]; P = .06). Kaplan-Meier incidence over 4 years was 0.042 (95% CI, 0.032 to 0.056) in the vitamin D^sub 3^ + calcium group and 0.060 (95% CI, 0.048 to 0.076) in the placebo group; P = .06. In unadjusted Cox proportional hazards regression, the hazard ratio was 0.70 (95% CI, 0.47 to 1.02). Adverse events potentially related to the study included renal calculi (16 participants in the vitamin D^sub 3^ + calcium group and 10 in the placebo group), and elevated serum calcium levels (6 in the vitamin D^sub 3^ + calcium group and 2 in the placebo group).
ISSN:0098-7484
1538-3598