Fos expression in rat spinal cord induced by peripheral injection of BmK I, an α-like scorpion neurotoxin

In this paper, the central neuronal activities elicited by BmK I, a specific voltage-gated Na + channel modulator, were examined by monitoring the c-Fos expression pattern of rat spinal cord. c-Fos protein in laminae I–II, V–VI, and VII–X could be detected at 0.5 h, increased steadily at 1 h, reache...

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Bibliographic Details
Published in:Toxicology and applied pharmacology 2003-10, Vol.192 (1), p.78-85
Main Authors: Bai, Zhan-Tao, Zhang, Xu-Ying, Ji, Yong-Hua
Format: Article
Language:English
Subjects:
Analgesics, Opioid - pharmacology
Animal poisons toxicology. Antivenoms
Animals
Behavior, Animal - drug effects
Biological and medical sciences
BmK I
Cell Count
Dose-Response Relationship, Drug
Fos protein
Gene Expression - drug effects
Genes, fos - drug effects
Immunohistochemistry
Male
Medical sciences
Morphine
Morphine - pharmacology
Na + channel modulator
Neurons - drug effects
Neurons - metabolism
Neurotoxins - administration & dosage
Neurotoxins - toxicity
Pain - chemically induced
Pain - psychology
Rats
Rats, Sprague-Dawley
Scorpion Venoms - administration & dosage
Scorpion Venoms - toxicity
Spinal cord
Spinal Cord - cytology
Spinal Cord - drug effects
Spinal Cord - metabolism
Toxicology
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Summary:In this paper, the central neuronal activities elicited by BmK I, a specific voltage-gated Na + channel modulator, were examined by monitoring the c-Fos expression pattern of rat spinal cord. c-Fos protein in laminae I–II, V–VI, and VII–X could be detected at 0.5 h, increased steadily at 1 h, reached a peak at 2 h, and then decreased rapidly from 4 to 24 h after Bmk I was subcutaneously injected into the rat hind paw. However, c-Fos expression in laminae III–IV was activated to a peak at 0.5 h and then declined gradually from 0.5 to 24 h. Furthermore, c-Fos expression could be induced by BmK I in a dose-dependent manner. In addition, the increase of c-Fos expression in laminae I–II, V–VI, and VII–X induced by BmK I, and not in laminae III–IV, could be partially inhibited by systemic morphine in a dose-dependent manner. The results suggested that peripheral administration of BmK I could evoke a profound change of spinal neuronal activities manifested as specific patterns of c-Fos expression, which may be partially attributed to the selective modulation of BmK I on voltage-gated Na + channels located in peripheral nociceptors.
ISSN:0041-008X
1096-0333
DOI:10.1016/S0041-008X(03)00260-6