Porous 45S5 Bioglass®-based scaffolds using stereolithography: Effect of partial pre-sintering on structural and mechanical properties of scaffolds

Scaffolds made from 45S5 Bioglass® ceramic (BG) show clinical potential in bone regeneration due to their excellent bioactivity and ability to bond to natural bone tissue. However, porous BG scaffolds are limited by their mechanical integrity and by the substantial volume contractions occurring upon...

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Bibliographic Details
Published in:Materials Science & Engineering C 2017-06, Vol.75, p.1281-1288
Main Authors: Thavornyutikarn, Boonlom, Tesavibul, Passakorn, Sitthiseripratip, Kriskrai, Chatarapanich, Nattapon, Feltis, Bryce, Wright, Paul F.A., Turney, Terence W.
Format: Article
Language:English
Subjects:
Bioactive glass
Biocompatibility
Bioglass
Biological activity
Bone growth
Bone tissue regeneration
Bones
CAD
Ceramics
Ceramics - chemistry
Compressive strength
Computer aided design
Diamonds
Glass
Glass - chemistry
Lithography
Materials science
Mechanical properties
Porosity
Porous scaffolds
Presintering
Regeneration
Regeneration (physiology)
Scaffolds
Shrinkage
Sintering (powder metallurgy)
Stereolithography
Tissue engineering
Tissue Scaffolds - chemistry
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Summary:Scaffolds made from 45S5 Bioglass® ceramic (BG) show clinical potential in bone regeneration due to their excellent bioactivity and ability to bond to natural bone tissue. However, porous BG scaffolds are limited by their mechanical integrity and by the substantial volume contractions occurring upon sintering. This study examines stereolithographic (SLA) methods to fabricate mechanically robust and porous Bioglass®-based ceramic scaffolds, with regular and interconnected pore networks and using various computer-aided design architectures. It was found that a diamond-like (DM) architecture gave scaffolds the most controllable results without any observable closed porosity in the fired scaffolds. When the pore dimensions of the DM scaffolds of the same porosity (~60vol%) were decreased from 700 to 400μm, the compressive strength values increased from 3.5 to 6.7MPa. In addition, smaller dimensional shrinkage could be obtained by employing partially pre-sintered bioglass, compared to standard 45S5 Bioglass®. Scaffolds derived from pre-sintered bioglass also showed marginally improved compressive strength. [Display omitted] •3D porous bioglass scaffolds with various architectures have been printed via a stereolithographic method.•Diamond-like structures provide interconnected pores, potentially suitable for osseointegration•Thermal pre-treatment of bioglass powders gave smaller dimensional shrinkage of sintered scaffolds.
ISSN:0928-4931
1873-0191
DOI:10.1016/j.msec.2017.03.001