Evaluation of Noncompletion Bias and Long-Term Adherence in a 10-Year Patient-Reported Outcome Monitoring Program in Clinical Routine

Abstract Background Currently there is little knowledge on real-life sustainability of routine patient-reported outcome (PRO) measurement and the representativeness of collected data. Objectives The investigation of routine PRO with regard to noncompletion bias and long-term adher- ence, considering...

Full description

Saved in:
Bibliographic Details
Published in:Value in health 2017-04, Vol.20 (4), p.610-617
Main Authors: Gamper, Eva Maria, MSc, PhD, Nerich, Virginie, PharmD, PhD, Sztankay, Monika, MSc, Martini, Caroline, MSc, Giesinger, Johannes M., MSc, PhD, Scarpa, Lorenza, MD, Buxbaum, Sabine, MD, Jeller, Martin, LPN, Holzner, Bernhard, MSc, PhD, Virgolini, Irene, MD
Format: Article
Language:English
Subjects:
Adherence
Adult
Aged
Bias
Cancer
Clinical outcomes
clinical routine
Computers, Handheld
Data processing
Evaluation
Feasibility
Feasibility Studies
Female
Health care
Health Status
Health Status Indicators
Humans
Internal Medicine
Logistic Models
Male
Measurement
Medical diagnosis
Medical research
Middle Aged
mode of assessment
Multivariate Analysis
Neoplasms - diagnosis
Neoplasms - radiotherapy
Odds Ratio
Patient Compliance
Patient Reported Outcome Measures
patient-reported outcomes
Patients
Questionnaires
Regression analysis
Representativeness
Retrospective Studies
Risk Factors
Sex Factors
Software
Surveys and Questionnaires
Sustainability
Time Factors
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background Currently there is little knowledge on real-life sustainability of routine patient-reported outcome (PRO) measurement and the representativeness of collected data. Objectives The investigation of routine PRO with regard to noncompletion bias and long-term adher- ence, considering the potential impact of mode of assessment (MOA) (paper-pencil vs. electronic PRO [ePRO]) and patient characteristics. Methods At our department, routine PRO measurement in oncological patients is being done since 2005 using different MOA (paper-pencil assessment until 2011 and ePRO assessment from 2011 onward). We analyzed two different patient groups: patients eligible in both periods (both-MOA group) and patients eligible in only one period (one-MOA group). The primary outcome was PRO noncompletion (100% missing questionnaires). The secondary outcome was poor PRO adherence (>20% missing questionnaires). Multivariate logistic regression models were developed, testing the impact of MOA and patient characteristics on the outcomes in the different patient groups. Results Data from 1484 eligible patients were included in the analyses. Most of the patients could be included in PRO assessment at least once. PRO noncompletion rates were clearly higher during paper-pencil assessment (odds ratios between 2.72 and 4.31), as were poor PRO adherence rates (odd ratio 2.23). Analyses of potential bias by patient characteristics showed that male patients had a higher risk of poor adherence. Other factors with significant impact were age, country, and cancer diagnosis, but results were indecisive. Conclusions ePRO increased the feasibility of our clinical routine PRO data for retrospective analyses by increasing completion rates. In general, potential completion bias regarding certain patient characteristics requires attention before generalizing results to the respective populations.
ISSN:1098-3015
1524-4733
DOI:10.1016/j.jval.2017.01.009