The Research on the Relationship of RAGE, LRP-1, and Aβ Accumulation in the Hippocampus, Prefrontal Lobe, and Amygdala of STZ-Induced Diabetic Rats

Diabetes mellitus (DM) has been regarded as an important risk factor for Alzheimer’s disease (AD), and diabetic patients and animals have shown cognitive dysfunction. More research has shown that the amyloid-β (Aβ), which is a hallmark of AD, was found deposited in the hippocampus of diabetic rats....

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Published in:Journal of molecular neuroscience 2017-05, Vol.62 (1), p.1-10
Main Authors: Ma, Lou-Yan, Fei, Yu-Lang, Wang, Xiao-Ye, Wu, Song-Di, Du, Jun-Hui, Zhu, Mei, Jin, Long, Li, Ming, Li, Hai-Long, Zhai, Jia-Jia, Ji, Lu-Peng, Ma, Ran-Ran, Liu, Song-Fang, Li, Mo, Ma, Li, Ma, Xiao-Rui, Qu, Qiu-Min, Lv, Ya-Li
Format: Article
Language:English
Subjects:
Amygdala - metabolism
Amyloid beta-Peptides - genetics
Amyloid beta-Peptides - metabolism
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cognition
Diabetes Mellitus, Experimental - metabolism
Hippocampus - metabolism
Low Density Lipoprotein Receptor-Related Protein-1 - genetics
Low Density Lipoprotein Receptor-Related Protein-1 - metabolism
Male
Maze Learning
Neurochemistry
Neurology
Neurosciences
Prefrontal Cortex - metabolism
Proteomics
Rats
Rats, Sprague-Dawley
Receptor for Advanced Glycation End Products - genetics
Receptor for Advanced Glycation End Products - metabolism
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Summary:Diabetes mellitus (DM) has been regarded as an important risk factor for Alzheimer’s disease (AD), and diabetic patients and animals have shown cognitive dysfunction. More research has shown that the amyloid-β (Aβ), which is a hallmark of AD, was found deposited in the hippocampus of diabetic rats. This Aβ accumulation is regulated by the receptor for advanced glycation end products (RAGE) and low-density lipoprotein receptor-related protein (LRP-1). However, the expression of RAGE and LRP-1 in diabetic rats is not very clear. In the present study, we used streptozotocin (STZ)-induced diabetic rats to investigate whether the expression of RAGE and LRP-1 is related to Aβ 1–42 deposition at the hippocampus, prefrontal lobe, and amygdala in DM. We found that diabetic rats had longer escape latency and less frequency of entrance into the target zone than that of the control group ( P  
ISSN:0895-8696
1559-1166
DOI:10.1007/s12031-017-0892-2