Aging and cancer: The role of macrophages and neutrophils

Highlights • Age-related changes to macrophages and neutrophils may impact on age-related diseases. • Aging coincides with a decline in anti-tumour immunity. • Imbalanced pro/anti-inflammatory signals may alter the tumor microenvironment. • Age-related changes to tissues that supply immune cells may...

Full description

Saved in:
Bibliographic Details
Published in:Ageing research reviews 2017-07, Vol.36, p.105-116
Main Authors: Jackaman, Connie, Tomay, Federica, Duong, Lelinh, Abdol Razak, Norbaini Bintu, Pixley, Fiona J, Metharom, Pat, Nelson, Delia J
Format: Article
Language:English
Subjects:
Aging - drug effects
Aging - immunology
Aging - metabolism
Animals
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Humans
Inflammation Mediators - antagonists & inhibitors
Inflammation Mediators - immunology
Inflammation Mediators - metabolism
Internal Medicine
Macrophages - drug effects
Macrophages - physiology
Neoplasms - drug therapy
Neoplasms - immunology
Neoplasms - metabolism
Neurology
Neutrophils - drug effects
Neutrophils - physiology
Obesity - drug therapy
Obesity - immunology
Obesity - metabolism
T-Lymphocytes - drug effects
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Age-related changes to macrophages and neutrophils may impact on age-related diseases. • Aging coincides with a decline in anti-tumour immunity. • Imbalanced pro/anti-inflammatory signals may alter the tumor microenvironment. • Age-related changes to tissues that supply immune cells may impact tumor growth.
ISSN:1568-1637
1872-9649
DOI:10.1016/j.arr.2017.03.008