Dietary fat content modulates the hypolipidemic effect of dietary inulin in rats

Scope Dietary fat content (low versus high fat) may modulate the serum lipid‐lowering effect of high‐performance (HP)‐inulin. This study investigated the effect of dietary HP‐inulin on metabolism in rats fed a low‐ or high‐fat diet. Methods and results Rats were fed a diet of 5% fat with 5% cellulos...

Full description

Saved in:
Bibliographic Details
Published in:Molecular nutrition & food research 2017-08, Vol.61 (8), p.n/a
Main Authors: Han, Kyu‐Ho, Yamamoto, Aiko, Shimada, Ken‐ichiro, Kikuchi, Hiroto, Fukushima, Michihiro
Format: Article
Language:English
Subjects:
Animals
Bacteria
Body Weight - drug effects
Cecum
Cecum - microbiology
Cellulose
Cholesterol
Cholesterol - metabolism
Degree of polymerization
Diet
Diet, High-Fat - adverse effects
Dietary fat
Dietary Fats - adverse effects
Dietary Fats - pharmacology
Excretion
Fatty Acids, Volatile - metabolism
Fecal lipid excretion
Fermentation
Gastrointestinal Microbiome - drug effects
High density lipoprotein
High fat diet
Hypolipidemic Agents - pharmacology
Inulin
Inulin - pharmacology
Lipids
Lipids - blood
Liver
Liver - drug effects
Liver - metabolism
Male
Metabolism
Oils & fats
Polymerization
Rats
Rats, Inbred F344
Rodents
Sterols
Triglycerides - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Scope Dietary fat content (low versus high fat) may modulate the serum lipid‐lowering effect of high‐performance (HP)‐inulin. This study investigated the effect of dietary HP‐inulin on metabolism in rats fed a low‐ or high‐fat diet. Methods and results Rats were fed a diet of 5% fat with 5% cellulose or 5% HP‐inulin (average degree of polymerization = 24) (low‐fat diet) or of 20% fat with 5% cellulose or 5% HP‐inulin (high‐fat diet) for 28 days. Total, HDL, and non‐HDL cholesterols, and triglyceride concentrations in the serum were measured along with total lipid content of liver and feces. Hepatic triglyceride and cholesterol, and fecal neutral and acidic sterol concentrations in total lipid were assessed. In addition, cecum SCFA levels and bacterial profiles were determined. The hypolipidemic effect of HP‐inulin differed depending on dietary fat content (5% versus 20%). Specifically, 5% inulin instead of cellulose in a semi‐purified diet significantly reduced serum lipid levels in rats fed a high‐fat diet, which was strongly associated with increased total lipid and neutral sterol excretion. Conclusion Dietary fat content modulates the hypolipidemic effect of dietary inulin. The hypolipidemic effect of inulin differs depending on dietary fat content (5 versus 20%). Specifically, 5% inulin instead of cellulose in a semi‐purified diet significantly reduces serum lipid levels in rats fed a high‐fat diet, which is strongly associated with increased total lipid and neutral sterol excretion. These results indicate that dietary fat content modulates the hypolipidemic effect of dietary inulin.
ISSN:1613-4125
1613-4133
DOI:10.1002/mnfr.201600635