Gene duplication can impart fragility, not robustness, in the yeast protein interaction network

The maintenance of duplicated genes is thought to protect cells from genetic perturbations, but the molecular basis of this robustness is largely unknown. By measuring the interaction of yeast proteins with their partners in wild-type cells and in cells lacking a paralog, we found that 22 out of 56...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) 2017-02, Vol.355 (6325), p.630-634
Main Authors:	Diss, Guillaume, Gagnon-Arsenault, Isabelle, Dion-Coté, Anne-Marie, Vignaud, Hélène, Ascencio, Diana I., Berger, Caroline M., Landry, Christian R.
Format:	Article
Language:	eng
Subjects:	Abundance Biological evolution Evolution Evolution, Molecular Fragility Gene Duplication Genes Genes, Duplicate Genetics Protein interaction Protein Interaction Maps - genetics Proteins Reproduction Reproduction (copying) Robustness Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism Yeast
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Summary:	The maintenance of duplicated genes is thought to protect cells from genetic perturbations, but the molecular basis of this robustness is largely unknown. By measuring the interaction of yeast proteins with their partners in wild-type cells and in cells lacking a paralog, we found that 22 out of 56 paralog pairs compensate for the lost interactions. An equivalent number of pairs exhibit the opposite behavior and require each other’s presence for maintaining their interactions. These dependent paralogs generally interact physically, regulate each other’s abundance, and derive from ancestral self-interacting proteins. This reveals that gene duplication may actually increase mutational fragility instead of robustness in a large number of cases.
ISSN:	0036-8075 1095-9203