3D Printed Modeling of the Mitral Valve for Catheter-Based Structural Interventions

As catheter-based structural heart interventions become increasingly complex, the ability to effectively model patient-specific valve geometry as well as the potential interaction of an implanted device within that geometry will become increasingly important. Our aim with this investigation was to c...

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Bibliographic Details
Published in:Annals of biomedical engineering 2017-02, Vol.45 (2), p.508-519
Main Authors: Vukicevic, Marija, Puperi, Daniel S., Jane Grande-Allen, K., Little, Stephen H.
Format: Article
Language:English
Subjects:
3D printing
Animals
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Biophysics
Cardiac Catheterization - instrumentation
Cardiac Catheterization - methods
Classical Mechanics
Echocardiography, Transesophageal
Female
Heart Valve Prosthesis
Humans
Imaging
Male
Materials selection
Mitral Valve - diagnostic imaging
Mitral Valve - physiopathology
Patients
Printing, Three-Dimensional
Repair
Shores
Stress-strain relationships
Swine
The Pursuit of Engineering the Ideal Heart Valve Replacement or Repair
Tomography, X-Ray Computed
Valves
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Summary:As catheter-based structural heart interventions become increasingly complex, the ability to effectively model patient-specific valve geometry as well as the potential interaction of an implanted device within that geometry will become increasingly important. Our aim with this investigation was to combine the technologies of high-spatial resolution cardiac imaging, image processing software, and fused multi-material 3D printing, to demonstrate that patient-specific models of the mitral valve apparatus could be created to facilitate functional evaluation of novel trans-catheter mitral valve repair strategies. Clinical 3D transesophageal echocardiography and computed tomography images were acquired for three patients being evaluated for a catheter-based mitral valve repair. Target anatomies were identified, segmented and reconstructed into 3D patient-specific digital models. For each patient, the mitral valve apparatus was digitally reconstructed from a single or fused imaging data set. Using multi-material 3D printing methods, patient-specific anatomic replicas of the mitral valve were created. 3D print materials were selected based on the mechanical testing of elastomeric TangoPlus materials (Stratasys, Eden Prairie, Minnesota, USA) and were compared to freshly harvested porcine leaflet tissue. The effective bending modulus of healthy porcine MV tissue was significantly less than the bending modulus of TangoPlus ( p  
ISSN:0090-6964
1573-9686
DOI:10.1007/s10439-016-1676-5