ALK rearrangement in specific subtypes of lung adenocarcinoma: immunophenotypic and morphological features

Lung adenocarcinomas are characterized by a variety of genetic and epigenetic changes that lead to activation of specific signaling pathways. This allowed the classification of lung adenocarcinomas according to genetic alterations and the clinical development of novel anticancer agents that affect t...

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Bibliographic Details
Published in:Medical oncology (Northwood, London, England) London, England), 2017-05, Vol.34 (5), p.76-76, Article 76
Main Authors: Possidente, Luciana, Landriscina, Matteo, Patitucci, Giuseppe, Borgia, Ludovica, Lalinga, Vittoria, Vita, Giulia
Format: Article
Language:English
Subjects:
Adenocarcinoma - enzymology
Adenocarcinoma - genetics
Adenocarcinoma - pathology
Adenocarcinoma of Lung
Aged
Aged, 80 and over
Anaplastic Lymphoma Kinase
DNA-Binding Proteins - biosynthesis
DNA-Binding Proteins - genetics
Female
Gene Rearrangement
Hematology
Humans
Immunophenotyping
In Situ Hybridization, Fluorescence
Internal Medicine
Lung Neoplasms - enzymology
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Paper
Pathology
Receptor Protein-Tyrosine Kinases - genetics
Receptor Protein-Tyrosine Kinases - metabolism
Transcription Factors
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Summary:Lung adenocarcinomas are characterized by a variety of genetic and epigenetic changes that lead to activation of specific signaling pathways. This allowed the classification of lung adenocarcinomas according to genetic alterations and the clinical development of novel anticancer agents that affect the activity of specific oncoproteins. In such a context, chromosomal rearrangements that cause constitutive activation of ALK gene define a category of lung adenocarcinomas that is amenable to targeted therapy with ALK inhibitors. Thus, a major issue of current research is to define the morphological and immunophenotypic features of lung ALK-rearranged adenocarcinomas to improve the selection of tumors suitable for molecular genotyping. ALK status was determined, by immunohistochemistry and fluorescence in situ hybridization, in 94 surgically resected lung adenocarcinomas and correlated with histomorphological parameters. Indeed, ALK rearrangement was observed in 10/94 (11%) lung adenocarcinomas and enriched in tumors with a predominant mucinous (46%; p  
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-017-0936-z