Mind over hormones; Sex differences in associations of well-being with IGF-I, IGFBP-3 and physical activity in the KORA-Age study

A ssociations between well-being, serum levels of insulin-like growth factor 1 (IGF-I), and its primary binding protein IGFBP-3, were examined in an epidemiologic study. The influence of physical activity on the effect of hormones on well-being was considered. Cross-sectional data from participants...

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Bibliographic Details
Published in:Experimental gerontology 2014-11, Vol.59, p.58-64
Main Authors: Emeny, R.T., Bidlingmaier, M., Lacruz, M.E., Linkohr, B., Peters, A., Reincke, M., Ladwig, K.H.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging
Aging - blood
Aging - physiology
Aging - psychology
Cross-Sectional Studies
Depression - blood
Female
Geriatric Assessment - methods
Humans
IGF-1
IGFBP-3
Insulin-Like Growth Factor Binding Protein 3 - blood
Insulin-Like Growth Factor I - metabolism
Male
Middle Aged
Motor Activity - physiology
Physical activity
Psychiatric Status Rating Scales
Psychometrics
Quality of Life
Sex Characteristics
Well-being
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Summary:A ssociations between well-being, serum levels of insulin-like growth factor 1 (IGF-I), and its primary binding protein IGFBP-3, were examined in an epidemiologic study. The influence of physical activity on the effect of hormones on well-being was considered. Cross-sectional data from participants of the KORA-Age study (n=985, age 64–93) was analyzed in sex-specific multivariable regressions of well-being (World Health Organization (WHO) -5) or ill-being (geriatric depression scale (GDS) -15). Models were adjusted for age, physical activity, sleep, BMI, smoking, and cognition. Adjusted WHO-5 means demonstrated the interaction between hormone quintiles with physical activity. Full models indicated that increased IGFBP-3 positively associated with well-being in women (β estimate=0.14, standard error (SE)=0.06) and less so in men (β=0.11, SE=0.07). IGF-I associated positively with depression (β=0.11, SE=0.06) and negatively with well-being (β=−0.11, SE=0.06) in women. Similar but not statistically discernable effects were observed in men. Adjusted mean WHO-5 scores illustrated the positive effect of physical activity and IGFBP-3 on well-being in women only. Opposite and independent associations of IGF-I and IGFBP-3 on well-being observed in women suggests neuroprotective effects of IGFBP-3 in age. •Associations of well-being (WHO-5) with IGF-I & IGFBP-3 were studied in older adults.•IGFBP-3 was associated with well-being independent of physical activity and IGF-I.•IGF-I was positively associated with the GDS-15 depression scale in women.•Physical activity improves well-being in women despite hormone levels.
ISSN:0531-5565
1873-6815
DOI:10.1016/j.exger.2014.08.001