Serum 25-hydroxyvitamin D cutoffs for functional bone measures in postmenopausal osteoporosis

Summary This study sought to determine the minimal serum 25-hydroxyvitamin D [25(OH)D] concentration required to maintain bone health in postmenopausal women with low bone mass. A serum 25(OH)D concentration of 20 ng/mL rather than 30 ng/mL was appropriate for bone health. Introduction There is no c...

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Bibliographic Details
Published in:Osteoporosis international 2017-04, Vol.28 (4), p.1377-1384
Main Authors: Lee, D. Y., Jee, J. H., Cho, Y. Y., Jang, J. Y., Yu, T. Y., Kim, T. H., Hong, Y. J., Hong, W.-J., Jin, S.-M., Hur, K. Y., Kim, J. H., Kim, S. W., Chung, J. H., Lee, M. K., Min, Y.-K.
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Aged
Alkaline phosphatase
Biochemical markers
Biomarkers - blood
Bone Density - physiology
Bone mass
Bone mineral density
Bone Remodeling - physiology
Bone turnover
Chromatography, Liquid - methods
Collagen
Cross-linking
Densitometry
Endocrinology
Female
Femur
Femur - physiopathology
Femur Neck - physiopathology
Humans
Liquid chromatography
Mass spectroscopy
Medical records
Medicine
Medicine & Public Health
Middle Aged
Neck
Original Article
Orthopedics
Osteopenia
Osteoporosis
Osteoporosis, Postmenopausal - blood
Osteoporosis, Postmenopausal - etiology
Osteoporosis, Postmenopausal - physiopathology
Parathyroid hormone
Parathyroid Hormone - blood
Post-menopause
Rheumatology
Studies
Tandem Mass Spectrometry - methods
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - complications
Vitamin D Deficiency - physiopathology
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Summary:Summary This study sought to determine the minimal serum 25-hydroxyvitamin D [25(OH)D] concentration required to maintain bone health in postmenopausal women with low bone mass. A serum 25(OH)D concentration of 20 ng/mL rather than 30 ng/mL was appropriate for bone health. Introduction There is no consensus on the minimal serum 25-hydroxyvitamin D [25(OH)D] concentration required to maintain bone health. The aim of this study was to investigate the relationship between 25(OH)D measured via liquid chromatography-mass spectrometry (LC–MS/MS), which is the current gold standard, and biochemical markers of bone turnover, PTH, and bone mineral densitometry (BMD). Methods The medical records of 750 postmenopausal women newly diagnosed with osteoporosis or osteopenia at Samsung Medical Center from 2009 to 2014 were investigated. Subjects were divided into four groups according to serum 25(OH)D concentration:
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-016-3892-0