Receptor-interacting Protein Kinase 3 Controls Keratinocyte Activation in a Necroptosis-independent Manner and Promotes Psoriatic Dermatitis in Mice

RIPK3 in keratinocytes facilitates psoriatic inflammation by promoting cytokine and chemokine production, independent of the induction of necroptosis. Control of RIPK3 activation may be a novel therapeutic target for psoriasis.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2017-08, Vol.140 (2), p.619-622.e6
Main Authors: Honda, Tetsuya, MD, PhD, Yamamoto, Osamu, MD, PhD, Sawada, Yu, MD, PhD, Egawa, Gyohei, MD, PhD, Kitoh, Akihiko, MD, PhD, Otsuka, Atsushi, MD, PhD, Dainichi, Teruki, MD, PhD, Nakajima, Saeko, MD, PhD, Miyachi, Yoshiki, MD, PhD, Kabashima, Kenji, MD, PhD
Format: Article
Language:English
Subjects:
Activation
Allergy and Immunology
Animals
Apoptosis
Apoptosis - genetics
Biomarkers
Bone marrow
Chemokines
Colitis
Cytokines
Dehydrogenases
Dendritic cells
Dermatitis
Dextran
Disease Models, Animal
Epidermis
Flow cytometry
Gangrene
Gene expression
Hyperplasia
Immunohistochemistry
Inflammation
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory diseases
Inflammatory response
Interleukin 24
Intestine
Keratinocytes
Keratinocytes - metabolism
Keratinocytes - pathology
Kinases
Lesions
Leukocytes (neutrophilic)
Mice
Mice, Knockout
Necroptosis
Necrosis - genetics
Necrosis - metabolism
Neutrophil Infiltration
Neutrophils
Organs
Pathogenesis
Polymerase chain reaction
Protein kinase
Proteins
Psoriasis
Psoriasis - genetics
Psoriasis - metabolism
Psoriasis - pathology
Receptor-Interacting Protein Serine-Threonine Kinases - genetics
Receptor-Interacting Protein Serine-Threonine Kinases - metabolism
Rodents
Sepsis
Skin diseases
Sodium
Sodium sulfate
Software
Sulfates
Systemic inflammatory response syndrome
Tumor necrosis factor-TNF
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Description
Summary:RIPK3 in keratinocytes facilitates psoriatic inflammation by promoting cytokine and chemokine production, independent of the induction of necroptosis. Control of RIPK3 activation may be a novel therapeutic target for psoriasis.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.02.027