Management and outcomes of acute pancreatitis patients over the last decade: A US tertiary-center experience

Abstract Background/objectives Acute pancreatitis (AP) management remains largely supportive and can be challenging in patients with severe disease. This study aims to describe a ten-year US tertiary-center experience in managing AP patients. Methods Clinical management and outcomes of 400 prospecti...

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Published in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2017-01, Vol.17 (1), p.32-40
Main Authors: Koutroumpakis, Efstratios, Slivka, Adam, Furlan, Alessandro, Dasyam, Anil K, Dudekula, Anwar, Greer, Julia B, Whitcomb, David C, Yadav, Dhiraj, Papachristou, Georgios I
Format: Article
Language:English
Subjects:
Acute pancreatitis
Endocrinology & Metabolism
Fluid Therapy
Gastroenterology and Hepatology
Humans
Management
Medical records
Mortality
Nutrition
Nutritional Support
Outcomes
Pancreatitis - epidemiology
Pancreatitis - therapy
Parenteral nutrition
Plasmapheresis
Retrospective Studies
Revised Atlanta classification
Tertiary Care Centers
Treatment Outcome
United States
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Summary:Abstract Background/objectives Acute pancreatitis (AP) management remains largely supportive and can be challenging in patients with severe disease. This study aims to describe a ten-year US tertiary-center experience in managing AP patients. Methods Clinical management and outcomes of 400 prospectively enrolled AP patients stratified by the Revised Atlanta Classification were analyzed; trends in management between early (2004–2008) and late enrollment phase (2009–2014) were assessed. Results Fifty-two% of patients were classified as mild AP (MAP); moderately severe (MoAP) and severe (SAP) grades contained 23.5% and 24.5% of participants. Intravenous fluid administration during the first 24 h (MAP 3.7, MoAP 4.7, and SAP 4.8 L), need for ICU (6%, 23%, 93%), and nutritional support (7%, 51%, 90%) increased significantly with greater AP severity (p 
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2016.10.011