Citric acid crosslinked β-cyclodextrin/carboxymethylcellulose hydrogel films for controlled delivery of poorly soluble drugs

•βCD-CMC hydrogel films were prepared using citric acid as a crosslinking agent.•The concentration of βCD in the feed affected the hydrogel properties.•The hydrogel films showed high drug loading.•The films were biocompatible and controlled the release of poorly soluble drug. Citric acid crosslinked...

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Bibliographic Details
Published in:Carbohydrate polymers 2017-05, Vol.164, p.339-348
Main Authors: Ghorpade, Vishwajeet Sampatrao, Yadav, Adhikrao Vyankatrao, Dias, Remeth Jacky
Format: Article
Language:English
Subjects:
beta-Cyclodextrins - chemistry
Carboxymethylcellulose
Carboxymethylcellulose Sodium - chemistry
Citric acid
Citric Acid - chemistry
Controlled release
Delayed-Action Preparations
Drug Carriers - chemistry
Hydrogel films
Ketoconazole - administration & dosage
Methylgalactosides - chemistry
β-Cyclodextrin
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Summary:•βCD-CMC hydrogel films were prepared using citric acid as a crosslinking agent.•The concentration of βCD in the feed affected the hydrogel properties.•The hydrogel films showed high drug loading.•The films were biocompatible and controlled the release of poorly soluble drug. Citric acid crosslinked β-cyclodextrin–carboxymethylcellulose (βCD-CMC) hydrogel films were prepared by esterification-crosslinking method for the controlled release of ketoconazole (model drug). The hydrogel films were evaluated for active βCD content, carboxyl content, swelling ratio, drug loading and release, and hemolytic activity. The structural characterization was carried out using solid state 13C NMR, ATR-FTIR, TGA and DSC analysis. The βCD-CMC hydrogel films showed increase in active βCD content swelling ratio and drug loading with increase in the concentration of βCD in the feed. The βCD helped to minimize the burst effect and retarded the release of ketoconazole. The hydrogel films were found to be biocompatible and capable of controlling the release of ketoconazole for long duration.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2017.02.005