Gd2O3 and GH combined with red blood cells to improve the sensitivity of contrast agents for cancer targeting MR imaging

Herein, we fabricated efficient MR imaging probes by incorporating gadolinium oxide nanoparticles (Gd2O3) and gadolinium hybrid nanoparticles (GH) within RBCs. The Gd2O3 and GH encapsulated in the RBCs exhibited high relaxation rates and revealed high sensitivity for T1 MR imaging.

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Bibliographic Details
Published in:Biomaterials science 2017-01, Vol.5 (1), p.46-49
Main Authors: Zhang, Kunchi, Cao, Yi, Kuang, Ye, Liu, Min, Chen, Yang, Wang, Zhili, Hong, Shanni, Wang, Jine, Pei, Renjun
Format: Article
Language:English
Subjects:
Biomedical materials
Encapsulation
Gadolinium
Gadolinium oxides
Nanoparticles
Red blood cells
Sensitivity
Surgical implants
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Description
Summary:Herein, we fabricated efficient MR imaging probes by incorporating gadolinium oxide nanoparticles (Gd2O3) and gadolinium hybrid nanoparticles (GH) within RBCs. The Gd2O3 and GH encapsulated in the RBCs exhibited high relaxation rates and revealed high sensitivity for T1 MR imaging.
ISSN:2047-4830
2047-4849
DOI:10.1039/c6bm00627b