Effects of photobiomodulation therapy, pharmacological therapy, and physical exercise as single and/or combined treatment on the inflammatory response induced by experimental osteoarthritis

Osteoarthritis (OA) triggers increased levels of inflammatory markers, including prostaglandin (PG) E 2 and proinflammatory cytokines. The elevation of cytokine levels is closely associated with increased articular tissue degeneration. Thus, the use of combination therapies may presumably be able to...

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Bibliographic Details
Published in:Lasers in medical science 2017-01, Vol.32 (1), p.101-108
Main Authors: Tomazoni, Shaiane Silva, Leal-Junior, Ernesto Cesar Pinto, Pallotta, Rodney Capp, Teixeira, Simone, de Almeida, Patricia, Lopes-Martins, Rodrigo Álvaro Brandão
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Arthritis
Biocompatibility
Biomedical materials
Combined Modality Therapy
Cytokines
Dentistry
Dinoprostone - blood
Disease Models, Animal
Drug therapy
Enzyme-Linked Immunosorbent Assay
Exercise
Gene expression
Gene Expression Regulation - drug effects
Humans
Inflammation - pathology
Interleukin-1beta - genetics
Interleukin-1beta - metabolism
Interleukin-6 - genetics
Interleukin-6 - metabolism
Knee Joint - metabolism
Laser surgery
Lasers
Low-Level Light Therapy
Male
Markers
Medicine
Medicine & Public Health
Optical Devices
Optics
Original Article
Osteoarthritis - blood
Osteoarthritis - genetics
Osteoarthritis - pathology
Osteoarthritis - therapy
Pharmacology
Photonics
Physical Conditioning, Animal
Physical exercise
Physical fitness
Proteins
Quantum Optics
Rats, Wistar
Real-Time Polymerase Chain Reaction
Therapy
Tumor Necrosis Factor-alpha - genetics
Tumor Necrosis Factor-alpha - metabolism
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Summary:Osteoarthritis (OA) triggers increased levels of inflammatory markers, including prostaglandin (PG) E 2 and proinflammatory cytokines. The elevation of cytokine levels is closely associated with increased articular tissue degeneration. Thus, the use of combination therapies may presumably be able to enhance the effects on the modulation of inflammatory markers. The present study aimed to evaluate and compare the effects of photobiomodulation therapy (PBMT), physical exercise, and topical nonsteroidal anti-inflammatory drug (NSAID) use on the inflammatory process after they were applied either alone or in different combinations. OA was induced by intra-articular papain injection in the knee of rats. After 21 days, the animals began treatment with a topical NSAID and/or with physical exercise and/or PBMT. Treatments were performed three times a week for eight consecutive weeks, totaling 24 therapy sessions. Analysis of real-time polymerase chain reaction (RT-PCR) gene expression; interleukin (IL)-1β, IL-6, and tumor necrosis factor alpha (TNF-α) protein expression; and PGE 2 levels by enzyme-linked immunosorbent assay (ELISA) was conducted. Our results showed that PBMT alone and Exerc + PBMT significantly reduced IL-1β gene expression ( p  
ISSN:0268-8921
1435-604X
DOI:10.1007/s10103-016-2091-8