40Hz auditory steady-state responses in patients with disorders of consciousness: Correlation between phase-locking index and Coma Recovery Scale-Revised score

•40Hz auditory steady-state response (ASSR) was evaluated in patients with disorders of consciousness.•Phase-locking index of 40Hz ASSR positively correlated with the clinical state of the brain-damaged patients.•Exploration of disorders of consciousness should include testing of the integrity of th...

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Bibliographic Details
Published in:Clinical neurophysiology 2017-05, Vol.128 (5), p.799-806
Main Authors: Binder, Marek, Górska, Urszula, Griskova-Bulanova, Inga
Format: Article
Language:English
Subjects:
40 Hz
Adult
Aged
Auditory steady-state response
Auditory system
Case-Control Studies
Consciousness Disorders - diagnosis
Consciousness Disorders - physiopathology
CRS-R score
Disorders of consciousness
Electroencephalography
Evoked Potentials, Auditory
Female
Humans
Male
Middle Aged
Trauma Severity Indices
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Summary:•40Hz auditory steady-state response (ASSR) was evaluated in patients with disorders of consciousness.•Phase-locking index of 40Hz ASSR positively correlated with the clinical state of the brain-damaged patients.•Exploration of disorders of consciousness should include testing of the integrity of the central auditory system. We aimed to elucidate whether 40Hz auditory steady-state response (ASSR) could be sensitive to the state of patients with disorders of consciousness (DOC) as estimated with Coma Recovery Scale-Revised (CRS-R) diagnostic tool. Fifteen DOC patients and 24 healthy controls took part in the study. The 40Hz click trains were used to evoke ASSRs. Mean evoked amplitude (EA) and phase-locking index (PLI) within 38–42Hz window were calculated for 100ms bins, starting from −200 to 700ms relative to stimulus onset. The PLI values from the patient group in the period of 200–500ms after the stimulus onset positively correlated with the CRS-R total score and with the scores of the Auditory and Visual subscales. The phase-locking index of 40Hz auditory steady-state responses can be an indicator of the level of dysfunction of the central nervous system in DOC. Our results emphasize the role of central auditory system integrity in determining the level of functioning of DOC patients and suggest the possibility to use the ASSR protocol as an objective diagnostic method in DOC patients.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2017.02.012