Asiatic acid ameliorates pulmonary fibrosis induced by bleomycin (BLM) via suppressing pro-fibrotic and inflammatory signaling pathways

Abstract Idiopathic pulmonary fibrosis is known as a life-threatening disease with high mortality and limited therapeutic strategies. In addition, the molecular mechanism by which pulmonary fibrosis developed is not fully understood. Asiatic acid (AA) is a triterpenoid, isolated from Centella asiati...

Full description

Saved in:
Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2017-05, Vol.89, p.1297-1309
Main Authors: Dong, Shu-Hong, Liu, Yan-Wei, Wei, Feng, Tan, Hui-Zhen, Han, Zhi-Dong
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - pharmacology
Asiatic acid (AA)
Bleomycin (BLM)
Bleomycin - pharmacology
Bronchoalveolar Lavage Fluid - cytology
Cell Line
Collagen Type I - metabolism
Collagen Type III - metabolism
Cytokines - metabolism
Fibrosis
Humans
Inflammation
Inflammation - drug therapy
Inflammation - metabolism
Internal Medicine
Lung - drug effects
Lung - metabolism
Lung Injury - chemically induced
Lung Injury - drug therapy
Lung Injury - metabolism
Male
MAP Kinase Signaling System - drug effects
Medical Education
Mice
Mice, Inbred C57BL
NLR Family, Pyrin Domain-Containing 3 Protein - metabolism
Pentacyclic Triterpenes - pharmacology
Pulmonary fibrosis
Pulmonary Fibrosis - chemically induced
Pulmonary Fibrosis - drug therapy
Pulmonary Fibrosis - metabolism
Signal Transduction - drug effects
Tissue Inhibitor of Metalloproteinase-1 - metabolism
Transforming Growth Factor beta1 - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Idiopathic pulmonary fibrosis is known as a life-threatening disease with high mortality and limited therapeutic strategies. In addition, the molecular mechanism by which pulmonary fibrosis developed is not fully understood. Asiatic acid (AA) is a triterpenoid, isolated from Centella asiatica, exhibiting efficient anti-inflammatory and anti-oxidative activities. In our study, we attempted to explore the effect of Asiatic acid on bleomycin (BLM)-induced pulmonary fibrosis in mice. The findings indicated that pre-treatment with Asiatic acid inhibited BLM-induced lung injury and fibrosis progression in mice. Further, Asiatic acid down-regulates inflammatory cells infiltration in bronchoalveolar lavage fluid (BALF) and pro-inflammatory cytokines expression in lung tissue specimens induced by BLM. Also, Asiatic acid apparently suppressed transforming growth factor-beta 1 (TGF-β1) expression in tissues of lung, accompanied with Collagen I, Collagen III, α-SMA and matrix metalloproteinase (TIMP)-1 decreasing, as well as Smads and ERK1/2 inactivation. Of note, Asiatic acid reduces NOD-like receptor, pyrin domain containing-3 (NLRP3) inflammasome. The findings indicated that Asiatic acid might be an effective candidate for pulmonary fibrosis and inflammation treatment.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2017.03.005