Hidden high rate of pre‐eclampsia in twin compared with singleton pregnancy

ABSTRACT Objectives To examine the gestational age at delivery in dichorionic (DC) and monochorionic (MC) twin pregnancies, with and without pre‐eclampsia (PE), and to determine the relative risk of total and preterm PE compared with that in singleton pregnancies. Methods This was a screening study...

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Bibliographic Details
Published in:Ultrasound in obstetrics & gynecology 2017-07, Vol.50 (1), p.88-92
Main Authors: Francisco, C., Wright, D., Benkő, Z., Syngelaki, A., Nicolaides, K. H.
Format: Article
Language:English
Subjects:
Adult
Age composition
Aneuploidy
Babies
Confounding Factors (Epidemiology)
England - epidemiology
Female
first‐trimester screening
Gestation
Gestational Age
Gynecology
Hazards
Health risk assessment
Humans
Incidence
Medical screening
Obstetrics
Pre-eclampsia
Pre-Eclampsia - epidemiology
Pre-Eclampsia - etiology
Preeclampsia
Pregnancy
Pregnancy Outcome
Pregnancy, Twin
pyramid of pregnancy care
Risk
Risk Factors
twin pregnancy
Twins
Twins, Dizygotic
Twins, Monozygotic
Ultrasonic imaging
Ultrasound
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Summary:ABSTRACT Objectives To examine the gestational age at delivery in dichorionic (DC) and monochorionic (MC) twin pregnancies, with and without pre‐eclampsia (PE), and to determine the relative risk of total and preterm PE compared with that in singleton pregnancies. Methods This was a screening study for PE in twin pregnancies undergoing first‐trimester combined screening for aneuploidy and subsequently delivering two phenotypically normal live or stillborn babies at ≥ 24 weeks' gestation. The distribution of gestational age at delivery in DC and MC twins was determined and compared with that in singleton pregnancies from the same population. The relative risk for total and preterm PE in twins compared with singleton pregnancies was determined. Kaplan–Meier estimates of the cumulative incidence of PE in twin and singleton pregnancies, assuming no other cause for delivery, were determined and hazard ratios for twins relative to singletons were obtained from a Cox proportional hazards regression model. Results The incidence of PE in singletons was 2.3% (2162/93 297), in DC twin pregnancies was 8.1% (145/1789) and in MC twin pregnancies was 6.0% (26/430). Compared with singletons, the relative risk of total PE was 3.5 for DC twins and 2.6 for MC twins. Delivery
ISSN:0960-7692
1469-0705
DOI:10.1002/uog.17470