Role of caveolin-1/vascular endothelial growth factor pathway in basic fibroblast growth factor-induced angiogenesis and neurogenesis after treadmill training following focal cerebral ischemia in rats

Highlights • Treadmill training attenuated the neurological deficit score and decreased infarct size, while bFGF shRNA increased infarct injury. • Treadmill training increased protein expression levels of bFGF, caveolin-1, and VEGF in the ischemic penumbra. • bFGF shRNA blocked the caveolin-1/VEGF p...

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Bibliographic Details
Published in:Brain research 2017-05, Vol.1663, p.9-19
Main Authors: Pang, Qiongyi, Zhang, Huimei, Chen, Zhenzhen, Wu, Yudan, Bai Liu, Min ，Yidian, Zhao, Yun, Tu, Fengxia, Liu, Chan, Chen, Xiang
Format: Article
Language:English
Subjects:
Angiogenesis
Angiogenesis Inducing Agents - metabolism
Animals
bFGF
Brain - metabolism
Brain Injuries - metabolism
Brain Ischemia - metabolism
Bromodeoxyuridine - metabolism
Caveolin 1 - metabolism
Disease Models, Animal
Exercise Test - methods
Fibroblast Growth Factor 2 - metabolism
Infarction, Middle Cerebral Artery - metabolism
Ischemic Attack, Transient - metabolism
Male
MCAO
Neurogenesis
Neurogenesis - physiology
Neurology
Neurons - metabolism
Physical Conditioning, Animal - physiology
Rats
Rats, Sprague-Dawley
Recovery of Function
shRNA
Stroke - physiopathology
Treadmill
Vascular Endothelial Growth Factor A - metabolism
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Summary:Highlights • Treadmill training attenuated the neurological deficit score and decreased infarct size, while bFGF shRNA increased infarct injury. • Treadmill training increased protein expression levels of bFGF, caveolin-1, and VEGF in the ischemic penumbra. • bFGF shRNA blocked the caveolin-1/VEGF pathway in the ischemic penumbra. • Treadmill training improved neural regeneration and enhanced angiogenesis, which effects were inhibited by bFGF shRNA, demonstrated by immunofluorescence. • Effects of caveolin-1/VEGF pathway on angiogenesis and neurogenesis after MCAO may be induced by bFGF after treadmill training.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2017.03.012