Serum adipocyte-fatty acid binding protein (FABP4) levels in women from Mexico exposed to polycyclic aromatic hydrocarbons (PAHs)

Recent studies indicate that exposure to polycyclic aromatic hydrocarbons (PAHs) is a very important risk factor for the development of cardiovascular diseases (CVDs). Correspondingly, adipocyte-fatty acid binding protein (FABP4, also known as aP2 and AFABP) has been proposed as a new, meaningful an...

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Bibliographic Details
Published in:Environmental science and pollution research international 2017, Vol.24 (2), p.1862-1870
Main Authors: Ochoa-Martínez, Ángeles C., Ruíz-Vera, Tania, Pruneda-Álvarez, Lucia G., González-Palomo, Ana K., Almendarez-Reyna, Claudia I., Pérez-Vázquez, Francisco J., Pérez-Maldonado, Iván N.
Format: Article
Language:English
Subjects:
1-Hydroxypyrene
Adipocytes
Adolescent
Adult
Aged
Air pollution
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Biomarkers
Biomarkers - urine
Cardiovascular diseases
Chromatography, High Pressure Liquid
Contaminants
Creatinine
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Exposure
Environmental Health
Environmental Pollutants - toxicity
Environmental science
Enzyme-linked immunosorbent assay
Epidemiology
Exposure
Fatty acid-binding protein
Fatty Acid-Binding Proteins - blood
Fatty acids
Female
Health risks
Heart diseases
High performance liquid chromatography
Humans
Liquid chromatography
Mexico
Middle Aged
Polycyclic aromatic hydrocarbons
Polycyclic Aromatic Hydrocarbons - toxicity
Pyrenes - urine
Research Article
Risk factors
Studies
Waste Water Technology
Water Management
Water Pollution Control
Young Adult
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Summary:Recent studies indicate that exposure to polycyclic aromatic hydrocarbons (PAHs) is a very important risk factor for the development of cardiovascular diseases (CVDs). Correspondingly, adipocyte-fatty acid binding protein (FABP4, also known as aP2 and AFABP) has been proposed as a new, meaningful and useful biomarker to predict metabolic and cardiovascular diseases. Therefore, the aim of this study was to evaluate serum FABP4 levels in Mexican women exposed to PAHs. Urinary 1-hydroxypyrene ((1-OHP), exposure biomarker for PAHs) levels were quantified using a high-performance liquid chromatography (HPLC) technique, and serum FABP4 concentrations were analyzed using a commercially available ELISA kit. The mean urinary 1-OHP level found in women participating in this study was 1.30 ± 1.10 μmol/mol creatinine (2.45 ± 2.10 μg/g creatinine). Regarding serum FABP4 concentrations, the levels ranged from 3.80 to 62.5 ng/mL in the assessed population. Moreover, a significant association ( p  
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-016-7971-8