An extra virgin olive oil rich diet intervention ameliorates the nonalcoholic steatohepatitis induced by a high‐fat “Western‐type” diet in mice

Scope We evaluated the protective effect of extra virgin olive oil (EVOO) in high‐fat diets (HFDs) on the inflammatory response and liver damage in a nonalcoholic fatty liver disease (NAFLD) mouse model. Methods and results C57BL/6J mice were fed a standard diet or a lard‐based HFD (HFD‐L) for 12 wk...

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Published in:Molecular nutrition & food research 2017-03, Vol.61 (3), p.np-n/a
Main Authors: Jurado‐Ruiz, Enrique, Varela, Lourdes M., Luque, Amparo, Berná, Genoveva, Cahuana, Gladys, Martinez‐Force, Enrique, Gallego‐Durán, Rocío, Soria, Bernat, Roos, Baukje, Romero Gómez, Manuel, Martín, Franz
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose Tissue - drug effects
Adipose Tissue - metabolism
Adipose Tissue - pathology
Animals
Body weight
Body Weight - drug effects
CD36 antigen
Composition effects
Cytokines - metabolism
Diet
Diet, High-Fat - adverse effects
Diet, Western - adverse effects
Disorders
Extra virgin olive oil (EVOO)
Fatty acids
Fatty liver
Gene expression
Gene Expression Regulation
High fat diet
Infiltration
Inflammation
Inflammatory response
Interleukin 6
Intervention
Leptin
Lipid composition
Lipid metabolism
Lipid Metabolism - drug effects
Lipid Metabolism - genetics
Lipids
Liver
Liver - drug effects
Liver - metabolism
Liver - pathology
Liver diseases
Macrophages
Male
Metabolic disorders
Metabolism
Mice
Mice, Inbred C57BL
Non-alcoholic Fatty Liver Disease - diet therapy
Non-alcoholic Fatty Liver Disease - etiology
Nonalcoholic fatty liver disease
Oils & fats
Oleic acid
Olive oil
Olive Oil - pharmacology
Organ Size - drug effects
Phospholipases A2, Calcium-Independent - genetics
Proteins
Regeneration
Reversion
Rodents
Triolein
Weight reduction
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Summary:Scope We evaluated the protective effect of extra virgin olive oil (EVOO) in high‐fat diets (HFDs) on the inflammatory response and liver damage in a nonalcoholic fatty liver disease (NAFLD) mouse model. Methods and results C57BL/6J mice were fed a standard diet or a lard‐based HFD (HFD‐L) for 12 wk to develop NAFLD. HFD‐fed mice were then divided into four groups and fed for 24 wk with the following: HFD‐L, HFD‐EVOO, HFD based on phenolics‐rich EVOO, and reversion (standard diet). HFD‐L‐induced metabolic disorders were alleviated by replacement of lard with EVOO. EVOO diets improved plasma lipid profile and reduced body weight, plasma and epididymal fat INF‐γ, IL‐6 and leptin levels, and macrophage infiltration. Moreover, NAFLD activity scores were reduced. The liver lipid composition showed an increase in MUFAs, especially oleic acid, and a decrease in saturated fatty acids. Hepatic adiponutrin and Cd36 gene expression was upregulated in the EVOO groups. Liver ingenuity pathway analysis revealed in EVOO groups regulation of proteins involved in lipid metabolism, small molecule biochemistry, gastrointestinal disease, and liver regeneration. Conclusion Dietary EVOO could repair HFD‐induced hepatic damage, possibly via an anti‐inflammatory effect in adipose tissue and modifications in the liver lipid composition and signaling pathways. Dietary fat may be an important modifiable factor involved in nonalcoholic fatty liver disease. The protective effect of extra virgin olive oil (EVOO) in high‐fat diets on the inflammatory response and liver damage is evaluated in a nonalcoholic fatty liver disease mouse model. EVOO diets improve plasma lipid profile, plasma and fat inflammation; ameliorate liver damage; increase MUFAs liver levels; and modify liver protein expression. Dietary EVOO could repair high‐fat diet induced hepatic damage via an anti‐inflammatory effect and changes in the liver lipid composition and signaling pathways.
ISSN:1613-4125
1613-4133
DOI:10.1002/mnfr.201600549