Intramolecular Minisci acylation under silver-free neutral conditions for the synthesis of azafluorenones and fluorenones

Despite its synthetic potential, intramolecular acylation by the Minisci reaction remains unexplored. The development of a new intramolecular Minisci acylation under silver-free neutral conditions providing access to azafluorenones and fluorenones is described. Distinct from the current literature k...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2017, Vol.15 (10), p.2199-2210
Main Authors: Laha, Joydev K, Patel, Ketul V, Dubey, Gurudutt, Jethava, Krupal P
Format: Article
Language:English
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Summary:Despite its synthetic potential, intramolecular acylation by the Minisci reaction remains unexplored. The development of a new intramolecular Minisci acylation under silver-free neutral conditions providing access to azafluorenones and fluorenones is described. Distinct from the current literature known approaches for Minisci acylation, the report described herein features a method that: (a) avoids the use of silver that is invariably used in Minisci acylation, (b) does not require any acidic conditions for the activation of pyridines, and
ISSN:1477-0520
1477-0539
DOI:10.1039/c7ob00077d