Immune cell subsets, cytokine and cortisol levels during the first week of life in neonates born to pre‐eclamptic mothers

Problem To address the hypothesis that pre‐eclampsia (PE) impacts the fetal immune system, we investigated the prevalence of distinct immune cell subsets along with plasma cortisol and cytokine levels in pre‐term newborns of PE mothers. Method of study Cord blood and peripheral blood samples on the...

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Bibliographic Details
Published in:American journal of reproductive immunology (1989) 2017-06, Vol.77 (6), p.n/a
Main Authors: Sava, Florentina, Toldi, Gergely, Treszl, András, Hajdú, Júlia, Harmath, Ágnes, Rigó, János, Tulassay, Tivadar, Vásárhelyi, Barna
Format: Article
Language:English
Subjects:
CD4
CD4 antigen
Cord blood
Cortisol
Cytokines
Cytokines - blood
Dendritic Cells - immunology
Female
Fetuses
Flow cytometry
HLA‐DR
Hormones
Humans
Hydrocortisone - blood
Immune status
Immunological memory
Infant, Newborn - immunology
Infants
Killer Cells, Natural - immunology
Lymphocytes T
Male
Memory cells
memory T cell
Mothers
Neonates
Peripheral blood
Pre-eclampsia
Pre-Eclampsia - immunology
Pregnancy
pre‐term neonate
T cell receptors
T-Lymphocyte Subsets - immunology
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Summary:Problem To address the hypothesis that pre‐eclampsia (PE) impacts the fetal immune system, we investigated the prevalence of distinct immune cell subsets along with plasma cortisol and cytokine levels in pre‐term newborns of PE mothers. Method of study Cord blood and peripheral blood samples on the 1st, 3rd and 7th postnatal days of life were collected from 14 pre‐term infants affected by PE and 14 non‐PE pregnancies. We measured plasma cortisol and cytokine levels with immunoassays and assessed the prevalence of T, NK and DC subsets using flow cytometry. Results The prevalence of CD4+ cells was lower in PE infants, while that of memory T cells was higher. Myeloid DCs had a lower prevalence in PE neonates. Cytokine and cortisol levels were lower in PE neonates. Conclusion Our observations show that PE pregnancies are associated with altered newborn immune status during the first week of life.
ISSN:1046-7408
1600-0897
DOI:10.1111/aji.12659