Evaluation of Antinociceptive and Anti-inflammatory Effects of Aqueous Extract of Armadillidium vulgare Latreille

Objective： To assess the antinociceptive and anti-inflammatory properties of the aqueous extract of Armadillidium vulgare（AV）. Methods： The antinociceptive effect of AV（400, 600 and 800 mg/kg） was investigated in mice using the acetic acid-induced writhing, formalin-induced nociceptive, and hot plat...

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Bibliographic Details
Published in:Chinese journal of integrative medicine 2017-02, Vol.23 (2), p.138-145
Main Authors: Guo, Shen-shen, Ren, Meng-yue, Song, Shuai, Wei, Ping, Luo, Jia-bo
Format: Article
Language:English
Subjects:
Analgesics - pharmacology
Animals
Anti-Inflammatory Agents - pharmacology
Edema - drug therapy
Female
Inflammation - drug therapy
Isopoda - chemistry
Male
Medicine
Medicine & Public Health
Mice
Original Article
Pain - drug therapy
Pain Measurement
Phytotherapy
Plant Extracts - chemistry
Plant Extracts - pharmacology
Water - chemistry
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Summary:Objective： To assess the antinociceptive and anti-inflammatory properties of the aqueous extract of Armadillidium vulgare（AV）. Methods： The antinociceptive effect of AV（400, 600 and 800 mg/kg） was investigated in mice using the acetic acid-induced writhing, formalin-induced nociceptive, and hot plate tests. Phlogogen-induced paw edema using carrageenan, dextran, or compound 48/80 as phlogogen was used as inflammatory models to evaluate AV＇s anti-inflammatory effect. Additionally, the bioactive substances glucosamine（GLc N） and taurine in AV were determined using high-performance liquid chromatography. Results： Oral treatment of the mice with AV（600 and 800 mg/kg） significantly reduced the number of writhes in the acetic acid-induced writhing test（P〈0.01） but not the hot plate test（P〉0.05）. All doses tested significantly inhibited paw-withdrawal during the second phase of the formalin-induced nociceptive model（P〈0.01）. AV demonstrated a strong anti-inflammatory effect in all those inflammatory models（P〈0.05）. Conclusions： AV has antinociceptive and anti-inflammatory effects, providing scientific evidence of the efficacy of its traditional use in pain treatment. Furthermore, GLc N and taurine contribute, at least in part, to the anti-inflammatory activity of AV.
ISSN:1672-0415
1993-0402
DOI:10.1007/s11655-016-2646-3