Controlling the morphology of copolymeric vectors for next generation nanomedicine

Amidst the wealth of information that the past few decades of nanomedical research has given us there is one design principle that has emerged as being key for the success of delivery vectors: particle morphology. This review seeks to unpack the various facets of particle morphology that are importa...

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Bibliographic Details
Published in:Journal of controlled release 2017-08, Vol.259, p.29-39
Main Authors: Williams, David S., Pijpers, Imke A.B., Ridolfo, Roxane, van Hest, Jan C.M.
Format: Article
Language:English
Subjects:
Animals
Drug delivery
Drug Delivery Systems
Drug Design
Nanomedicine
Nanoparticles
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Nanovectors
Polymers - administration & dosage
Polymers - chemistry
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Summary:Amidst the wealth of information that the past few decades of nanomedical research has given us there is one design principle that has emerged as being key for the success of delivery vectors: particle morphology. This review seeks to unpack the various facets of particle morphology that are important for effective integration in vivo. In order to understand the contribution of morphology towards the biophysical function of nanovectors it is important to consider the historical development of such systems and how their physicochemical characteristics are selected. Ultimately, the purpose of this review is to give a clear perspective for the development of future nanovectors and how an integrated approach to their design, with particular focus upon their morphological features (size, shape, stimuli-responsiveness and surface chemistry), is vital for their performance in vitro and in vivo. [Display omitted]
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2017.02.030