CRTC2 polymorphism as a risk factor for the incidence of metabolic syndrome in patients with solid organ transplantation

Metabolic syndrome after transplantation is a major concern following solid organ transplantation (SOT). The CREB-regulated transcription co-activator 2 (CRTC2) regulates glucose metabolism. The effect of CRTC2 polymorphisms on new-onset diabetes after transplantation (NODAT) was investigated in a d...

Full description

Saved in:
Bibliographic Details
Published in:The pharmacogenomics journal 2017-01, Vol.17 (1), p.69-75
Main Authors: Quteineh, L, Bochud, P-Y, Golshayan, D, Crettol, S, Venetz, J-P, Manuel, O, Kutalik, Z, Treyer, A, Lehmann, R, Mueller, N J, Binet, I, van Delden, C, Steiger, J, Mohacsi, P, Dufour, J-F, Soccal, P M, Pascual, M, Eap, C B
Format: Article
Language:English
Subjects:
Body mass index
Body weight
Cholesterol
Cyclic AMP response element-binding protein
Diabetes mellitus
Diabetes Mellitus - epidemiology
Diabetes Mellitus - genetics
Dyslipidemias - epidemiology
Dyslipidemias - genetics
Gene Frequency
Gene polymorphism
Genetic Predisposition to Disease
Genotype & phenotype
Glucose metabolism
Heterozygote
High density lipoprotein
Homozygote
Humans
Hyperlipidemia
Incidence
Kidney transplantation
Linear Models
Logistic Models
Metabolic syndrome
Metabolic Syndrome - diagnosis
Metabolic Syndrome - epidemiology
Metabolic Syndrome - genetics
Multivariate Analysis
Obesity
Obesity - epidemiology
Obesity - genetics
Odds Ratio
Organ Transplantation - adverse effects
Overweight
Phenotype
Polymorphism, Single Nucleotide
Prevalence
Replication
Risk Assessment
Risk Factors
Switzerland - epidemiology
Tacrolimus
Time Factors
Transcription
Transcription Factors - genetics
Transplants & implants
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Metabolic syndrome after transplantation is a major concern following solid organ transplantation (SOT). The CREB-regulated transcription co-activator 2 (CRTC2) regulates glucose metabolism. The effect of CRTC2 polymorphisms on new-onset diabetes after transplantation (NODAT) was investigated in a discovery sample of SOT recipients (n =197). Positive results were tested for replication in two samples from the Swiss Transplant Cohort Study (STCS, n =1294 and n =759). Obesity and other metabolic traits were also tested. Associations with metabolic traits in population-based samples (n =46'186, n =123'865, n >100,000) were finally analyzed. In the discovery sample, CRTC2 rs8450-AA genotype was associated with NODAT, fasting blood glucose and body mass index (P A was significantly associated with several metabolic abnormalities. CRTC2 rs8450G>A appears to have an important role in the high prevalence of metabolic traits observed in patients with SOT. A weak association with metabolic traits was also observed in the population-based samples.
ISSN:1470-269X
1473-1150
DOI:10.1038/tpj.2015.82