Dengue-associated hemophagocytic lymphohistiocytosis in an adult. A case report and literature review

Infection-associated hemophagocytic syndrome (IAHS) is potentially a fatal disease caused by systemic infection complicated by hemophagocyticlymphohistiocytosis (HLH). Here, we report a case of HLH associated with dengue hemorrhagic fever (DHF) after a trip to Thailand. A 33-year-old healthy female...

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Bibliographic Details
Published in:Medicine (Baltimore) 2017-02, Vol.96 (8), p.e6159-e6159, Article e6159
Main Authors: Chung, Sang Mi, Song, Joon Young, Kim, Wonshik, Choi, Min Joo, Jeon, Ji Ho, Kang, Seonghui, Jung, Eunju, Noh, Ji Yun, Cheong, Hee Jin, Kim, Woo Joo
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Adult
Diagnosis, Differential
Early Diagnosis
Female
Humans
Lymphohistiocytosis, Hemophagocytic - complications
Lymphohistiocytosis, Hemophagocytic - diagnosis
Lymphohistiocytosis, Hemophagocytic - drug therapy
Lymphohistiocytosis, Hemophagocytic - pathology
Severe Dengue - complications
Severe Dengue - diagnosis
Severe Dengue - drug therapy
Severe Dengue - pathology
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Summary:Infection-associated hemophagocytic syndrome (IAHS) is potentially a fatal disease caused by systemic infection complicated by hemophagocyticlymphohistiocytosis (HLH). Here, we report a case of HLH associated with dengue hemorrhagic fever (DHF) after a trip to Thailand. A 33-year-old healthy female patient presented with 3 days of fever, myalgia, and skin rash. Serotype 3 dengue virus was isolated. Clinical and laboratory findings fulfilled the criteria of HLH. After the initiation of corticosteroid therapy, the patient recovered and laboratory findings were normalized. It would be important to differentially diagnose dengue-associated HLH from severe DHF. Early recognition and initiation of steroid treatment would be crucial for the successful treatment of dengue fever complicated by HLH.
ISSN:0025-7974
1536-5964
DOI:10.1097/md.0000000000006159