One-Pot Cascade Synthesis of Substituted Carbazoles from Indoles, Ketones, and Alkenes Using Oxygen as the Oxidant

An efficient one-pot two-step indole-to-carbazole strategy has been developed. This transition metal-free methodology uses oxygen as the sole oxidant and starts from cheap and readily available indoles, ketones, and alkenes. The present protocol efficiently enables the assembly of a diverse array of...

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Bibliographic Details
Published in:Journal of organic chemistry 2017-03, Vol.82 (6), p.2935-2942
Main Authors: Chen, Shanping, Li, Yuxia, Ni, Penghui, Yang, Baichuan, Huang, Huawen, Deng, Guo-Jun
Format: Article
Language:English
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Summary:An efficient one-pot two-step indole-to-carbazole strategy has been developed. This transition metal-free methodology uses oxygen as the sole oxidant and starts from cheap and readily available indoles, ketones, and alkenes. The present protocol efficiently enables the assembly of a diverse array of substituted carbazole products with good regioselectivity and broad tolerance of functional groups.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.6b02892