Catalytic Enantioselective Transformations Involving C–H Bond Cleavage by Transition-Metal Complexes

The development of new methods for the direct functionalization of unactivated C–H bonds is ushering in a paradigm shift in the field of retrosynthetic analysis. In particular, the catalytic enantioselective functionalization of C–H bonds represents a highly atom- and step-economic approach toward t...

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Bibliographic Details
Published in:Chemical reviews 2017-07, Vol.117 (13), p.8908-8976
Main Authors: Newton, Christopher G, Wang, Shou-Guo, Oliveira, Caio C, Cramer, Nicolai
Format: Article
Language:English
Subjects:
Asymmetry
Carbon
Catalysis
Chemistry
Coordination compounds
Ductile-brittle transition
Fracture mechanics
Hydrogen bonds
Metal complexes
Metals
Stereochemistry
Stereoselectivity
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Summary:The development of new methods for the direct functionalization of unactivated C–H bonds is ushering in a paradigm shift in the field of retrosynthetic analysis. In particular, the catalytic enantioselective functionalization of C–H bonds represents a highly atom- and step-economic approach toward the generation of structural complexity. However, as a result of their ubiquity and low reactivity, controlling both the chemo- and stereoselectivity of such processes constitutes a significant challenge. Herein we comprehensively review all asymmetric transition-metal-catalyzed methodologies that are believed to proceed via an inner-sphere-type mechanism, with an emphasis on the nature of stereochemistry generation. Our analysis serves to document the considerable and rapid progress within in the field, while also highlighting limitations of current methods.
ISSN:0009-2665
1520-6890
DOI:10.1021/acs.chemrev.6b00692