Gestational weight gain, prepregnancy body mass index and offspring attention‐deficit hyperactivity disorder symptoms and behaviour at age 10

Objective To assess offspring attention‐deficit hyperactivity disorder (ADHD) symptoms and emotional/behavioural impairments at age 10 years in relation to maternal gestational weight gain (GWG) and prepregnancy body mass index (BMI). Design and setting Longitudinal birth cohort from Magee‐Womens Ho...

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Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2016-12, Vol.123 (13), p.2094-2103
Main Authors: Pugh, SJ, Hutcheon, JA, Richardson, GA, Brooks, MM, Himes, KP, Day, NL, Bodnar, LM
Format: Article
Language:English
Subjects:
Age
Attention
Attention Deficit Hyperactivity Disorder
Behavior disorders
Behavioral psychology
behaviour
Body mass
Body Mass Index
Body weight
Body weight gain
Child psychology
Children
Cohort Studies
Emotional behavior
Gestational Age
gestational weight gain
Humans
Hyperactivity
Impulsive behavior
Maternal behavior
maternal obesity
Mothers
Obesity
Obesity - epidemiology
Offspring
Overweight
Overweight - epidemiology
Pregnancy
Risk factors
Substance use
Weight
Weight Gain
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Summary:Objective To assess offspring attention‐deficit hyperactivity disorder (ADHD) symptoms and emotional/behavioural impairments at age 10 years in relation to maternal gestational weight gain (GWG) and prepregnancy body mass index (BMI). Design and setting Longitudinal birth cohort from Magee‐Womens Hospital, Pittsburgh, Pennsylvania (enrolled 1983–86). Population Mother–infant dyads (n = 511) were followed through pregnancy to 10 years. Methods Self‐reported total GWG was converted to gestational‐age‐standardised z‐scores. Multivariable linear and negative binomial regressions were used to estimate effects of GWG and BMI on outcomes. Main outcome measures Child ADHD symptoms were assessed with the Conners’ Continuous Performance Test. Child behaviour was assessed by parent and teacher ratings on the Child Behaviour Checklist (CBCL) and Teacher Report Form, respectively. Results The mean (SD) total GWG (kg) was 14.5 (5.9), and 10% of women had a pregravid BMI ≥30 kg/m2. Prepregnancy obesity (BMI of 30 kg/m2) was associated with increased offspring problem behaviours including internalising behaviours (adjusted β 3.3 points, 95% CI 1.7–4.9), externalising behaviours (adjusted β 2.9 points, 95% CI 1.4–4.6), and attention problems (adjusted β 2.3 points, 95% CI 1.1–3.4) on the CBCL, compared with normal weight mothers (BMI of 22 kg/m2). There were nonsignificant trends towards increased offspring impulsivity with low GWG among lean mothers (adjusted incidence rate ratio 1.2, 95% CI 0.9–1.5) and high GWG among overweight mothers (adjusted incidence rate ratio 1.7, 95% CI 0.9–2.8), but additional outcomes did not differ by GWG z‐score. Results were not meaningfully different after excluding high‐substance users. Conclusions In a low‐income and high‐risk sample, we observed a small increase in child behaviour problems among children of obese mothers, which could have an impact on child behaviour in the population. Tweetable Maternal obesity is associated with a small increase in child behaviour problems. Tweetable Maternal obesity is associated with a small increase in child behaviour problems.
ISSN:1470-0328
1471-0528
1471-0528
DOI:10.1111/1471-0528.13909