Vaccine provision: Delivering sustained & widespread use

Highlights • 100–500 different Quality Control tests assess vaccine safety, potency and purity. • 70% of time needed for manufacturing is dedicated to Quality Control activities. • Vaccine development typically takes 10–30 years but can be expedited in emergencies. • Single-dose vials avoid preserva...

Full description

Saved in:
Bibliographic Details
Published in:Vaccine 2016-12, Vol.34 (52), p.6665-6671
Main Authors: Preiss, Scott, Garçon, Nathalie, Cunningham, Anthony L, Strugnell, Richard, Friedland, Leonard R
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antigens
Chromatography
Clinical trials
Clinical Trials as Topic
Cold chain
Complexity
Data collection
Drug Approval
Drug delivery systems
Drug Discovery - methods
Drug Evaluation, Preclinical - methods
Humans
Immunogenicity
Immunology
Influenza
Licenses
Manufacturing
Mass spectrometry
Meningitis
New technology
Organic chemistry
Outbreaks
Pandemics
Pathogens
Quality control
Regulatory agencies
Safety
Scientific imaging
Shortages
Specifications
Storage temperature
Supply
Syringes
Technology, Pharmaceutical - methods
Temperature requirements
Vaccine
Vaccines
Vaccines - administration & dosage
Vaccines - immunology
Vaccines - isolation & purification
Viral diseases
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • 100–500 different Quality Control tests assess vaccine safety, potency and purity. • 70% of time needed for manufacturing is dedicated to Quality Control activities. • Vaccine development typically takes 10–30 years but can be expedited in emergencies. • Single-dose vials avoid preservatives but significantly impact on supply and cost. • Most vaccines require strict temperature control (cold chain) for continued potency.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2016.10.079