Impact of weight gain on the evolution and regression of prediabetes: a quantitative analysis

The quantitative impact of weight gain on prediabetic glucose dysregulation remains unknown; only one study quantitated the impact of weight loss. We quantified the impact of weight gain on the evolution and regression of prediabetes (PDM). In 4234 subjects without diabetes, using logistic regressio...

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Bibliographic Details
Published in:European journal of clinical nutrition 2017-02, Vol.71 (2), p.206-211
Main Authors: Nakasone, Y, Miyakoshi, T, Sato, Y, Yamauchi, K, Hashikura, R, Takayama, M, Hirabayashi, K, Koike, H, Aizawa, T
Format: Article
Language:English
Subjects:
Adult
Blood Glucose - analysis
Blood Glucose - metabolism
Body Mass Index
Development and progression
Diabetes
Diabetes mellitus
Disease Progression
Evolution
Female
Follow-Up Studies
Glucose
Glucose Tolerance Test
Health aspects
Humans
Logistic Models
Longitudinal Studies
Male
Men
Metabolic disorders
Middle Aged
Obesity
Odds Ratio
Prediabetic state
Prediabetic State - blood
Prediabetic State - physiopathology
Quantitative analysis
Regression analysis
Retrospective Studies
Risk Factors
Sex Factors
Weight Gain
Weight loss
Women
Womens health
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Summary:The quantitative impact of weight gain on prediabetic glucose dysregulation remains unknown; only one study quantitated the impact of weight loss. We quantified the impact of weight gain on the evolution and regression of prediabetes (PDM). In 4234 subjects without diabetes, using logistic regression analysis with a 4.8-year follow-up period, we analyzed the relationship between (1) δBMI (BMI ) and the progression from normal glucose regulation (NGR) to PDM or diabetes, and (2) δBMI and the regression from PDM to NGR. Mean (±s.d.) δBMI was 0.17 (±1.3) kg/m in subjects with NGR and δBMI was positively and independently related to progression (adjusted odds ratio (OR ) (95% CI), 1.24 (1.15-1.34), P
ISSN:0954-3007
1476-5640
DOI:10.1038/ejcn.2016.118