Efficacy of Methylprednisolone Acetate Versus Triamcinolone Acetonide Intra-Articular Knee Injection in Patients With Chronic Inflammatory Arthritis: A 24-Week Randomized Controlled Trial

Abstract Purpose Triamcinolone hexacetonide (TH), triamcinolone acetonide (TA), and methylprednisolone acetate (MPA) are commonly used intra-articular steroid preparations. Studies suggest that intra-articular TH is more efficacious than MPA and TA in chronic inflammatory arthritis. However, it is u...

Full description

Saved in:
Bibliographic Details
Published in:Clinical therapeutics 2017-01, Vol.39 (1), p.150-158
Main Authors: Kumar, Ashwani, MD, Dhir, Varun, MD, DM, Sharma, Shefali, MD, Sharma, Aman, MD, Singh, Surjit, MD
Format: Article
Language:English
Subjects:
Adult
Aged
Arthritis, Rheumatoid - drug therapy
Chronic Disease
Clinical trials
Double-Blind Method
Female
Health risk assessment
Humans
India
Infections
inflammatory arthritis
Injections, Intra-Articular
Internal Medicine
intra-articular injection
Knee Joint
Male
Medical Education
Methylprednisolone - administration & dosage
Methylprednisolone - analogs & derivatives
Methylprednisolone Acetate
Middle Aged
Pain
Pain - drug therapy
Pain Measurement
Patients
Questionnaires
Recurrence
Rheumatoid arthritis
Rheumatology
steroid
Steroids
Treatment Outcome
triamcinolone acetonide
Triamcinolone Acetonide - administration & dosage
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Purpose Triamcinolone hexacetonide (TH), triamcinolone acetonide (TA), and methylprednisolone acetate (MPA) are commonly used intra-articular steroid preparations. Studies suggest that intra-articular TH is more efficacious than MPA and TA in chronic inflammatory arthritis. However, it is unclear which of the latter two preparations has better efficacy. Thus, we compared intra-articular knee injections of MPA and TA in patients with chronic inflammatory arthritis. Methods This double-blind, randomized controlled trial included patients with rheumatoid arthritis or spondyloarthritis with an acutely swollen knee joint (≥1 week,
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2016.11.023