Lead Generation of Anti-allergic Agent ; Suplatast Tosilate

The reaction of transmethylation plays an important role in the immune system. Some kinds of sulfonium compounds, which have a labile methyl group, are considered to become the supply source for methyl groups in biological systems. We examined the physicochemical properties of sulfonium compounds fr...

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Bibliographic Details
Published in:Chem-Bio Informatics Journal 2001, Vol.1(1), pp.51-59
Main Authors: Tada, Yukio, Yamawaki, Ichiro, Ueda, Shu-ichi, Matsumoto, Hiroshi, Matsuura, Naosuke, Yasumoto, Mitsugi, Koda, Akihide, Hori, Mikio
Format: Article
Language:jpn ; eng
Subjects:
Suplatast Tosialate
Sulfonium Compound
Antiallergy Drug
Ion Pairs
Transport Rate
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Summary:The reaction of transmethylation plays an important role in the immune system. Some kinds of sulfonium compounds, which have a labile methyl group, are considered to become the supply source for methyl groups in biological systems. We examined the physicochemical properties of sulfonium compounds from the point of structure activity relationships analysis in order to develop an antiallergy drug. We found that several sulfonium compounds have immunological activity, and 2-hydroxyethyldimethylsulfonium p-toluenesulfonate (4) was chosen as the lead compound for further studies.
ISSN:1347-6297
1347-0442
DOI:10.1273/cbij.1.51