Macular Carotenoids, Aerobic Fitness, and Central Adiposity Are Associated Differentially with Hippocampal-Dependent Relational Memory in Preadolescent Children

Objectives To examine the associations of macular pigment carotenoids (lutein, meso -zeaxanthin, and zeaxanthin), aerobic fitness, and central adiposity with hippocampal-dependent relational memory in prepubescent children. Study design Children between 7 and 10 years of age (n = 40) completed a tas...

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Bibliographic Details
Published in:The Journal of pediatrics 2017-04, Vol.183, p.108-114.e1
Main Authors: Hassevoort, Kelsey M., BA, Khazoum, Sarah E., BA, Walker, John A., PhD, Barnett, Sasha M., MA, Raine, Lauren B., PhD, Hammond, Billy R., PhD, Renzi-Hammond, Lisa M., PhD, Kramer, Arthur F., PhD, Khan, Naiman A., PhD, Hillman, Charles H., PhD, Cohen, Neal J., PhD
Format: Article
Language:English
Subjects:
Age Factors
Biomarkers - metabolism
Carotenoids - metabolism
Child
childhood
Cohort Studies
development
Female
health factors
Hippocampus - metabolism
Hippocampus - physiology
Humans
Lutein - metabolism
Macula Lutea - metabolism
Male
Memory - physiology
Memory Disorders - diagnosis
Memory Disorders - metabolism
MPOD
Obesity, Abdominal - diagnosis
Pediatrics
Photometry
Physical Fitness - physiology
Prospective Studies
Regression Analysis
Sensitivity and Specificity
swap error
Zeaxanthins - metabolism
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Summary:Objectives To examine the associations of macular pigment carotenoids (lutein, meso -zeaxanthin, and zeaxanthin), aerobic fitness, and central adiposity with hippocampal-dependent relational memory in prepubescent children. Study design Children between 7 and 10 years of age (n = 40) completed a task designed to assess relational memory performance and participated in aerobic fitness, adiposity, and macular pigment optical density (MPOD) assessment. Aerobic fitness was assessed via a modified Balke treadmill protocol designed to measure maximal oxygen volume. Central adiposity was assessed via dual-energy x-ray absorptiometry. MPOD was measured psychophysically by the use of customized heterochromatic flicker photometry. Statistical analyses included correlations and hierarchical linear regression. Results Aerobic fitness and MPOD were associated negatively with relational memory errors ( P  
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2017.01.016