Correlation between tumour characteristics, SUV measurements, metabolic tumour volume, TLG and textural features assessed with 18F-FDG PET in a large cohort of oestrogen receptor-positive breast cancer patients

Purpose The study was designed to evaluate 1) the relationship between PET image textural features (TFs) and SUVs, metabolic tumour volume (MTV), total lesion glycolysis (TLG) and tumour characteristics in a large prospective and homogenous cohort of oestrogen receptor-positive (ER+) breast cancer (...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2017-07, Vol.44 (7), p.1145-1154
Main Authors: Lemarignier, Charles, Martineau, Antoine, Teixeira, Luis, Vercellino, Laetitia, Espié, Marc, Merlet, Pascal, Groheux, David
Format: Article
Language:English
Subjects:
Biopsy
Breast cancer
Cardiology
Chemotherapy
Correlation analysis
Energy
Energy measurement
Entropy
Fluorine isotopes
Glycolysis
Homogeneity
Image processing
Image segmentation
Imaging
Medicine
Medicine & Public Health
Metabolism
Metastases
Nuclear Medicine
Oncology
Original Article
Orthopedics
Patients
Positron emission
Positron emission tomography
Radiology
Tomography
Tumors
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Summary:Purpose The study was designed to evaluate 1) the relationship between PET image textural features (TFs) and SUVs, metabolic tumour volume (MTV), total lesion glycolysis (TLG) and tumour characteristics in a large prospective and homogenous cohort of oestrogen receptor-positive (ER+) breast cancer (BC) patients, and 2) the capability of those parameters to predict response to neoadjuvant chemotherapy (NAC). Methods 171 consecutive patients with large or locally advanced ER+ BC without distant metastases underwent an 18 F-FDG PET examination before NAC. The primary tumour was delineated with an adaptive threshold segmentation method. Parameters of volume, intensity and texture (entropy, homogeneity, contrast and energy) were measured and compared with tumour characteristics determined on pre-treatment breast biopsy (Wilcoxon rank-sum test). The correlation between PET-derived parameters was determined using Spearman’s coefficient. The relationship between PET features and pathological findings was determined using the Wilcoxon rank-sum test. Results Spearman’s coefficients between SUV max and TFs were 0.43, 0.24, -0.43 and -0.15 respectively for entropy, homogeneity, energy and contrast; they were higher between MTV and TFs: 0.99, 0.86, -0.99 and -0.87. All TFs showed a significant association with the histological type (IDC vs. ILC; 0.02 < P  
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-017-3641-4