Chronologic changes in serum hepatitis B virus DNA, genotypes, surface antigen mutants and reverse transcriptase mutants during 25‐year nationwide immunization in Taiwan

Summary We investigated breakthrough infection and hepatitis B virus (HBV) genetic changes in immunized subjects after 25 years of a universal infant immunization. Specifically, serum HBV DNA, genotypes, surface antigen mutants and nucleoside analog‐resistant (NAr) mutants were assessed in 2853 subj...

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Bibliographic Details
Published in:Journal of viral hepatitis 2017-08, Vol.24 (8), p.645-653
Main Authors: Hsu, H.‐Y., Chang, M.‐H., Ni, Y.‐H., Chiang, C.‐L., Wu, J.‐F., Chen, H.‐L., Chen, P.‐J., Chen, D.‐S.
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Age
Antigens
Child
Child, Preschool
Deoxyribonucleic acid
DNA
DNA, Viral - analysis
DNA, Viral - genetics
Female
genotype
Genotypes
HBV DNA
Hepatitis
Hepatitis B
Hepatitis B surface antigen
Hepatitis B Surface Antigens - genetics
Hepatitis B Vaccines - administration & dosage
Hepatitis B virus - classification
Hepatitis B virus - genetics
Hepatitis B virus - isolation & purification
Hepatitis B, Chronic - epidemiology
Hepatitis B, Chronic - virology
Humans
Immunization
Infant
Infections
Interferon
Male
Mutant Proteins - genetics
Nucleic acids
Nucleoside analogs
nucleoside analog‐resistant (NAr) mutants
occult HBV infection
RNA-directed DNA polymerase
RNA-Directed DNA Polymerase - genetics
Serum - virology
surface antigen mutants
Taiwan - epidemiology
Time Factors
Vaccination
Young Adult
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Description
Summary:Summary We investigated breakthrough infection and hepatitis B virus (HBV) genetic changes in immunized subjects after 25 years of a universal infant immunization. Specifically, serum HBV DNA, genotypes, surface antigen mutants and nucleoside analog‐resistant (NAr) mutants were assessed in 2853 subjects (
ISSN:1352-0504
1365-2893
DOI:10.1111/jvh.12687