Changes in liver stiffness measurements and fibrosis scores following sofosbuvir based treatment regimens without interferon

Background and Aim Accurate evaluation of the degree of liver fibrosis in patients with chronic liver diseases is crucial, as liver fibrosis is important in order to make therapeutic decisions, determine prognosis of liver disease and to follow‐up disease progression. Multiple non‐invasive methods h...

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Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2017-09, Vol.32 (9), p.1624-1630
Main Authors: Elsharkawy, Aisha, Alem, Shereen Abdel, Fouad, Rabab, El Raziky, Maissa, El Akel, Wafaa, Abdo, Mahmoud, Tantawi, Omnia, AbdAllah, Mohamed, Bourliere, Marc, Esmat, Gamal
Format: Article
Language:English
Subjects:
Adult
Antiviral agents
Antiviral Agents - administration & dosage
chronic hepatitis C virus
Elasticity Imaging Techniques
Female
Fibrosis
fibrosis scores
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - pathology
Humans
Interferon
Interferons
Liver
Liver - pathology
Liver diseases
Male
Middle Aged
Platelets
Regression Analysis
Retrospective Studies
Sofosbuvir - administration & dosage
Sofosbuvir‐based treatment
transient elastography
Treatment Outcome
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Summary:Background and Aim Accurate evaluation of the degree of liver fibrosis in patients with chronic liver diseases is crucial, as liver fibrosis is important in order to make therapeutic decisions, determine prognosis of liver disease and to follow‐up disease progression. Multiple non‐invasive methods have been used successfully in the prediction of fibrosis; however, early changes in non‐invasive biomarkers of hepatic fibrosis under effective antiviral therapy are widely unknown. The aim of this study is to evaluate changes of transient elastography values as well as FIB‐4 and AST to platelet ratio index (APRI) in patients treated with Sofosbuvir‐based treatment regimen. Methods This is a retrospective study including 337 chronic HCV Egyptian patients with genotype 4 mainly. They were treated with Sofosbuvir‐based treatment regimen. Transient elastography values were recorded as well as FIB‐4 and APRI were calculated at baseline and SVR12. Results There was a significant improvement of platelets counts, ALT and AST levels, which in turn cause significant improvement in FIB‐4 and APRI scores at SVR12. Liver stiffness measurements were significantly lower in SVR12 (14.8 ± 10.7 vs 11.8 ± 8.8 kPa, P = 0.000). About 77% of responders and 81.1% of cirrhotic patients showed improvement in liver stiffness measurements at SVR12.Univariate and multivariate regression analysis showed that failure to achieve improvement in liver stiffness measurements were significantly associated with relapsers and low baseline liver stiffness measurement. Conclusion Sofosbuvir‐based treatment resulted in a clinically significant improvement in parameters of liver fibrosis.
ISSN:0815-9319
1440-1746
DOI:10.1111/jgh.13758