Protective Effects of Genipin on Gastrointestinal Disorders

Genipin, an aglycone of geniposide, is a major component of gardeniae fructus, and has been used to treat jaundice, various inflammatory disorders, and liver disease, and has also been used as a natural cross-linking agent. The authors conducted several experiments to evaluate the protective effects...

Full description

Saved in:
Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2017/02/01, Vol.40(2), pp.151-154
Main Authors: Sohn, Yoon Ah, Hwang, In Young, Lee, Sun Yi, Cho, Hyo Sun, Jeong, Choon Sik
Format: Article
Language:eng ; jpn
Subjects:
Animals
Cell Line, Tumor
Ethanol
Gastric cancer
gastric secretion
Gastritis
Gastrointestinal Agents - pharmacology
Gastrointestinal Agents - therapeutic use
Gastrointestinal diseases
Gastrointestinal Diseases - metabolism
Gastrointestinal Diseases - pathology
Gastrointestinal Diseases - prevention & control
gastrointestinal disorder
Genipin
Indomethacin
Inflammatory diseases
Iridoids - pharmacology
Iridoids - therapeutic use
Jaundice
Lesions
Liver
Liver diseases
Male
Neutralization
Prostaglandin E2
Protective Agents - pharmacology
Protective Agents - therapeutic use
proton pump
Rats
Rats, Sprague-Dawley
Rodents
Secretion
Treatment Outcome
Ulcers
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Genipin, an aglycone of geniposide, is a major component of gardeniae fructus, and has been used to treat jaundice, various inflammatory disorders, and liver disease, and has also been used as a natural cross-linking agent. The authors conducted several experiments to evaluate the protective effects of genipin on gastrointestinal disorders, such as, gastritis and gastric ulcers. Genipin showed inhibitory effects against HCl·ethanol-induced acute gastritis and indomethacin-induced gastric ulcers in rats and increased prostaglandin E2 (PGE2) in AGS gastric cancer cell. Genipin had significant effects on aggressive factors, acid-neutralization, and gastric secretion, and inhibited H+/K+-ATPase (a proton pump), which secretes gastric acid. The results obtained indicate that genipin has significant gastroprotective effects and might be useful for treating and preventing gastric lesions.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b16-00545